Although several mechanisms have been proposed to underlie observed neuropsychological deficits and subsequent recovery of function following Mild Traumatic Brain Injury (MTBI), to date the link between alterations in axonal morphology, large scale neural functioning and behavioral recovery has not been established. This proposal represents an integrated approach to establishing a connection between structural damage resulting from MTBI, consequent deficits in neural functioning and the outward manifestations of cognitive and behavioral symptoms. The approach is both discovery-based and hypothesis driven, in which animal models of neural reorganization and regeneration, as well as possible cognitive compensatory processes are subject to empirical test. The accessibility to pre-injury baseline measures in athletes makes concussion an ideal entry point into the prospective study of MTBI and recovery of function. Over five consecutive years, pre-season baseline measures will be collected from FAU football players (N=80/year) on a Comprehensive Imaging Protocol for the Assessment of Concussion (CIPAC). The CIPAC will employ a combination of: a) functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), b) a Web-based neurocognitive assessment battery designed specifically for prospective testing (Concussion Resolution Index, Headminder Inc.), c) the NeuroCom(R) sensory organization test and d) self reported symptoms. Players identified as suffering a concussion during the course of the season will enter a post-concussion recording schedule in which they will be tested within 24 hours following injury and at regular intervals during recovery and during follow-up at 1 and 3 months. In this prospective approach, pre-injury levels of behavioral and neural functioning acquired during baseline testing will be used to evaluate post-concussion deficits independently for each individual. Particular focus will be on questions concerning: 1) the morphological, physiological and behavioral consequences of (multiple) concussions; 2) mechanisms of plasticity and recovery of function following MTBI; 3) the relationship between deficits in neural functioning and standardized behavioral measures of concussion; and 4) the implications for current assessment techniques and return to play guidelines. This individualized approach should provide important insights into the structural and dynamic mechanisms underlying recovery of function in the human brain.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS048229-04
Application #
7341702
Study Section
Clinical Neuroscience and Disease Study Section (CND)
Program Officer
Hicks, Ramona R
Project Start
2004-12-15
Project End
2009-11-30
Budget Start
2007-12-01
Budget End
2009-11-30
Support Year
4
Fiscal Year
2008
Total Cost
$305,939
Indirect Cost
Name
Florida Atlantic University
Department
Internal Medicine/Medicine
Type
Schools of Arts and Sciences
DUNS #
004147534
City
Boca Raton
State
FL
Country
United States
Zip Code
33431
Kelso, J A Scott (2012) Multistability and metastability: understanding dynamic coordination in the brain. Philos Trans R Soc Lond B Biol Sci 367:906-18
Chapin, Heather L; Zanto, Theodore; Jantzen, Kelly J et al. (2010) Neural responses to complex auditory rhythms: the role of attending. Front Psychol 1:224
Chapin, Heather; Jantzen, Kelly; Kelso, J A Scott et al. (2010) Dynamic emotional and neural responses to music depend on performance expression and listener experience. PLoS One 5:e13812
Kelso, J A Scott (2010) Instabilities and phase transitions in human brain and behavior. Front Hum Neurosci 4:23
Jantzen, Kelly J (2010) Functional magnetic resonance imaging of mild traumatic brain injury. J Head Trauma Rehabil 25:256-66
De Luca, Cinzia; Jantzen, Kelly J; Comani, Silvia et al. (2010) Striatal activity during intentional switching depends on pattern stability. J Neurosci 30:3167-74
Kelso, J A Scott (2009) Synergies: atoms of brain and behavior. Adv Exp Med Biol 629:83-91
Tognoli, Emmanuelle; Kelso, J A Scott (2009) Brain coordination dynamics: true and false faces of phase synchrony and metastability. Prog Neurobiol 87:31-40
Fink, Philip W; Kelso, J A Scott; Jirsa, Viktor K (2009) Perturbation-induced false starts as a test of the jirsa-kelso excitator model. J Mot Behav 41:147-57
Jantzen, Kelly J; Steinberg, Fred L; Kelso, J A Scott (2009) Coordination dynamics of large-scale neural circuitry underlying rhythmic sensorimotor behavior. J Cogn Neurosci 21:2420-33

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