The purpose of this research partnership is to investigate the functional implications of using sensor feedback to enhance motor control of the arm post-stroke. Two key functional aspects of motor control of the arm will be examined: 1) Reach, which involves coordinated actions of the shoulder and elbow musculature and 2) grasp, which incorporates both finger position and force controls. For each system, we will demonstrate that sensory feedback from nonhomologous joints has a significant effect on motor control. Initially, we will examine the intralimb reflex coupling of wrist/hand sensory feedback on elbow and shoulder musculature and visa versa.
For Aim 1 of this study, we will show that motorized stretch of the elbow and fingers produces reflex activity in muscles that are not perturbed. These effects will be compared between post-stroke and neurologically intact individuals using tendon tap perturbations. Sensory manipulations consisting of posture electrical stimulation, vibration and anesthesia will be used to modify the heteronymous reflex responses. Having demonstrated reflex coupling across joints, we will then examine the effects that this reflex coupling may have on motor function.
In Aim 2, motor control tasks of the upper arm (e.g. reach) will be tested during sensory manipulations of the fingers and wrist. Similarly, motor tasks of the hand will be tested with modifications of sensory inputs to the elbow and shoulder. These studies will demonstrate that sensory signals from nonhomologous joints can substantialy enhance motor function. The results of this study will suggest a new type of approach for rehabilitation of arm function post-stroke. We postulate that substantial improvements in arm function can be achieved by developing new technologies that provide artificial sensory feedback. In addition, conventional therapies may be applied more efficiently or effectively using the principles that will be demonstrated by this study.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS052509-03
Application #
7234402
Study Section
Special Emphasis Panel (ZRG1-RPHB-H (50))
Program Officer
Chen, Daofen
Project Start
2005-09-01
Project End
2009-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
3
Fiscal Year
2007
Total Cost
$274,297
Indirect Cost
Name
Marquette University
Department
Biomedical Engineering
Type
Schools of Engineering
DUNS #
046929621
City
Milwaukee
State
WI
Country
United States
Zip Code
53201
Conrad, Megan O; Gadhoke, Bani; Scheidt, Robert A et al. (2015) Effect of Tendon Vibration on Hemiparetic Arm Stability in Unstable Workspaces. PLoS One 10:e0144377
Conrad, Megan O; Scheidt, Robert A; Schmit, Brian D (2011) Effects of wrist tendon vibration on arm tracking in people poststroke. J Neurophysiol 106:1480-8
Hoffmann, Gilles; Schmit, Brian D; Kahn, Jennifer H et al. (2011) Effect of sensory feedback from the proximal upper limb on voluntary isometric finger flexion and extension in hemiparetic stroke subjects. J Neurophysiol 106:2546-56
Conrad, Megan O; Scheidt, Robert A; Schmit, Brian D (2011) Effects of wrist tendon vibration on targeted upper-arm movements in poststroke hemiparesis. Neurorehabil Neural Repair 25:61-70
Hoffmann, Gilles; Kamper, Derek G; Kahn, Jennifer H et al. (2009) Modulation of stretch reflexes of the finger flexors by sensory feedback from the proximal upper limb poststroke. J Neurophysiol 102:1420-9
Sangani, Samir G; Starsky, Andrew J; McGuire, John R et al. (2007) Multijoint reflexes of the stroke arm: neural coupling of the elbow and shoulder. Muscle Nerve 36:694-703
Scheidt, Robert A; Stoeckmann, Tina (2007) Reach adaptation and final position control amid environmental uncertainty after stroke. J Neurophysiol 97:2824-36