The white matter of the human brain is made up of axons that typically travel together in bundles called fascicles. Recent advances in Magnetic Resonance Imaging (MRI) has made it possible to image the self- diffusion of water molecules through Diffusion-Weighted MRI (DWMRI). Because water diffuses significantly more along axons than across them, DWMRI allows one to probe the microarchitecture of the white matter of the living human brain for the first time. In this project, we propose to build models of fascicles by grouping individual fiber models derived from DWMRI data based on the surrounding anatomy. We hypothesize that the anatomy through which a tract passes is predictive of the location of the tract, thus providing information about what fascicle each fiber should be assigned to. The resulting algorithms will provide automated tools for the modeling of the major fascicles in the human brain.
Connectivity tools are difficult for clinicians and researchers to use as they require manual interventions to generate reliable tract models. Automation will facilitate the analysis of connectivity in disorders such as schizophrenia, AD, autism and aging for subtle effects that occur early in brain disorders.
| Fischl, Bruce; Sereno, Martin I (2018) Microstructural parcellation of the human brain. Neuroimage 182:219-231 |
| Magnain, Caroline; Augustinack, Jean C; Tirrell, Lee et al. (2018) Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann's area 32 and area 21. Brain Struct Funct : |
| Li, Yi; Barkovich, Matthew J; Karch, Celeste M et al. (2018) Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex. Sci Rep 8:13373 |
| Siless, Viviana; Chang, Ken; Fischl, Bruce et al. (2018) AnatomiCuts: Hierarchical clustering of tractography streamlines based on anatomical similarity. Neuroimage 166:32-45 |
| Polimeni, Jonathan R; Renvall, Ville; Zaretskaya, Natalia et al. (2018) Analysis strategies for high-resolution UHF-fMRI data. Neuroimage 168:296-320 |
| Zaretskaya, Natalia; Fischl, Bruce; Reuter, Martin et al. (2018) Advantages of cortical surface reconstruction using submillimeter 7 T MEMPRAGE. Neuroimage 165:11-26 |
| Wang, Hui; Magnain, Caroline; Wang, Ruopeng et al. (2018) as-PSOCT: Volumetric microscopic imaging of human brain architecture and connectivity. Neuroimage 165:56-68 |
| Greve, Douglas N; Fischl, Bruce (2018) False positive rates in surface-based anatomical analysis. Neuroimage 171:6-14 |
| Bianciardi, Marta; Strong, Christian; Toschi, Nicola et al. (2018) A probabilistic template of human mesopontine tegmental nuclei from in vivo 7T MRI. Neuroimage 170:222-230 |
| Aganj, Iman; Harisinghani, Mukesh G; Weissleder, Ralph et al. (2018) Unsupervised Medical Image Segmentation Based on the Local Center of Mass. Sci Rep 8:13012 |
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