Stroke remains the leading cause of long-term disability in the US. Neural plasticity is thought to be one of the major mechanisms underlying functional recovery after central nervous system CNS injury. Because neuronal networks are highly plastic and reorganize with activity, changes at the neuronal network level are very likely to underlie major and fundamental aspects of ischemia-related functional deficits and recovery. Constraint-induced movement therapy (CIMT), the forced use of the affected limb by immobilization of the healthy limb, has shown promise in enhancing motor function recovery in some chronic stroke patients, with unexpect benefit in increasing hippocampal gray matter volume. Despite a myriad of consequences following CIMT have been well documented, including enhanced neuronal sprouting and synapse formation, improved cortical representation of motor output and reduced excitability of contralateral cortex, changes in neuroplasticity at the network level and the restoration of function of remote brain regions are not well understood. With multidisciplinary approaches, the main goal of this proposal will determine whether CIMT restores neocortical-hippocampal network, enhances hippocampal neurogenesis and function.

Public Health Relevance

Stroke affects the function of brain regions far away from the area that directly suffers from the ischemic attack. This intriguing neurological phenomenon has been described in 1914 among the scientific community and remains poorly understood. We have developed and characterized an animal model of stroke to study the mechanism of this type of brain dysfunction. To extend our previous findings, we will determine whether motor enrichment attenuates ischemia-induced disruption of neocortical-hippocampal network activity and promotes endogenous regeneration.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Research Project (R01)
Project #
Application #
Study Section
Brain Injury and Neurovascular Pathologies Study Section (BINP)
Program Officer
Bosetti, Francesca
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Northern California Institute Research & Education
San Francisco
United States
Zip Code
Neumann, Melanie; Liu, Wei; Sun, Chongran et al. (2018) Training of the impaired forelimb after traumatic brain injury enhances hippocampal neurogenesis in the Emx1 null mice lacking a corpus callosum. Behav Brain Res 340:165-171
Schmitt, O; Badurek, S; Liu, W et al. (2017) Prediction of regional functional impairment following experimental stroke via connectome analysis. Sci Rep 7:46316
Nishijima, Yasuo; Akamatsu, Yosuke; Yang, Shih Yen et al. (2016) Impaired Collateral Flow Compensation During Chronic Cerebral Hypoperfusion in the Type 2 Diabetic Mice. Stroke 47:3014-3021
Kobeissy, Firas H; Hansen, Katharina; Neumann, Melanie et al. (2016) Deciphering the Role of Emx1 in Neurogenesis: A Neuroproteomics Approach. Front Mol Neurosci 9:98
Nishijima, Yasuo; Akamatsu, Yosuke; Weinstein, Phillip R et al. (2015) Collaterals: Implications in cerebral ischemic diseases and therapeutic interventions. Brain Res 1623:18-29
Akamatsu, Yosuke; Nishijima, Yasuo; Lee, Chih Cheng et al. (2015) Impaired leptomeningeal collateral flow contributes to the poor outcome following experimental stroke in the Type 2 diabetic mice. J Neurosci 35:3851-64
Rabiller, Gratianne; He, Ji-Wei; Nishijima, Yasuo et al. (2015) Perturbation of Brain Oscillations after Ischemic Stroke: A Potential Biomarker for Post-Stroke Function and Therapy. Int J Mol Sci 16:25605-40
Liu, Jialing (2015) Poststroke angiogenesis: blood, bloom, or brood? Stroke 46:e105-6
Liu, Jialing (2014) LOX-1 and neurodegeneration. Neurosci Lett 580:179-81
Liu, Jialing; Wang, Yongting; Akamatsu, Yosuke et al. (2014) Vascular remodeling after ischemic stroke: mechanisms and therapeutic potentials. Prog Neurobiol 115:138-56

Showing the most recent 10 out of 13 publications