The long-term goal of our research is to investigate mechanisms to restore and optimize facial movement in cases of facial paralysis. The specific goal of the proposed research is to develop and study the long-term feasibility of a functional electrical stimulation (FES) paradigm to restore dynamic symmetrical facial motion in a rodent model of unilateral facial palsy (UFP). We will utilize conductive polymer electrode arrays to detect normal rodent facial muscle EMG activity on one side of the face, and nerve cuff electrodes to evoke contralateral-side corresponding muscle activity. We will couple the two systems via an implantable signal acquisition and generation platform, and anticipate that digital signal processing can be applied to trigger near- simultaneous and symmetric facial movement in rodents with UFP. We will begin by establishing the relationship between EMG activity and normal rodent facial movement, and the relationship between neural stimulation and evoked facial movements, under the hypothesis that there exists a mathematical model that links electrical and functional data. We will then construct a control algorithm for online processing of EMG input signals to drive FES, to examine the hypothesis that it is possible to subjugate the movements on one side of the face to normal movements on the opposite side. Importantly, we will also introduce proximal neural blockade on the subjugated side in order to prevent undesired physiologic activation of the facial musculature, to mimic clinically relevant scenarios for the application of these devices. Finally, we plan to implement the FES paradigm using a novel implantable neuroprosthetic device powered through inductive coupling, and demonstrate that neither the device, the presence of electrodes, nor the application of electrical stimulation induces neuropathy or myopathy in the long term. Knowledge gained from this research would be of immediate impact to the implementation of an analogous system in humans suffering from UFP, and provide significant impetus for the re-establishment of motor-neuron input to preserve native facial musculature following severe facial nerve injury. Furthermore, the novel approach proposed here could be applied to other clinical scenarios ? such as functional muscle and nerve transfers ? where poor control and undesirable physiologic activation of a muscle occurs.

Public Health Relevance

Facial paralysis is a source of enormous disability in the United States, and lacks consistently effective treatment to restore eyeblink, smile, facial expression, and speech articulation. We propose to develop and test an implantable neuroprosthetic device, which employs custom electrode arrays to sense distinct facial movements in the healthy hemi-face, and provides corresponding functional electrical stimulation to drive muscle movements in the paralyzed hemi-face. Data acquired in a rodent model will inform design of an analogous device for human implantation, with the goal of restoring symmetric facial movement in cases of unilateral facial paralysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS071067-10
Application #
9893030
Study Section
Acute Neural Injury and Epilepsy Study Section (ANIE)
Program Officer
Bambrick, Linda Louise
Project Start
2010-07-01
Project End
2021-03-31
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
10
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Massachusetts Eye and Ear Infirmary
Department
Type
DUNS #
073825945
City
Boston
State
MA
Country
United States
Zip Code
02114
Chen, Pei; Knox, Christopher J; Yao, Linli et al. (2017) The effects of venous ensheathment on facial nerve repair in the rat. Laryngoscope 127:1558-1564
Weinberg, Julie S; Kleiss, Ingrid J; Knox, Christopher J et al. (2016) The Dilator Naris Muscle as a Reporter of Facial Nerve Regeneration in a Rat Model. Ann Plast Surg 76:94-8
Banks, Caroline A; Knox, Christopher; Hunter, Daniel A et al. (2015) Long-term functional recovery after facial nerve transection and repair in the rat. J Reconstr Microsurg 31:210-6
Hohman, Marc H; Kim, Sang W; Heller, Elizabeth S et al. (2014) Determining the threshold for asymmetry detection in facial expressions. Laryngoscope 124:860-5
Frigerio, Alice; Hadlock, Tessa A; Murray, Elizabeth H et al. (2014) Infrared-based blink-detecting glasses for facial pacing: toward a bionic blink. JAMA Facial Plast Surg 16:211-8
Kleiss, Ingrid J; Knox, Christopher J; Malo, Juan S et al. (2014) Whisking recovery after automated mechanical stimulation during facial nerve regeneration. JAMA Facial Plast Surg 16:133-9
Bhama, Prabhat K; Weinberg, Julie S; Lindsay, Robin W et al. (2014) Objective outcomes analysis following microvascular gracilis transfer for facial reanimation: a review of 10 years' experience. JAMA Facial Plast Surg 16:85-92
Hohman, Marc H; Kleiss, Ingrid J; Knox, Christopher J et al. (2014) Functional recovery after facial nerve cable grafting in a rodent model. JAMA Facial Plast Surg 16:20-4
Heaton, James T; Sheu, Shu Hsien; Hohman, Marc H et al. (2014) Rat whisker movement after facial nerve lesion: evidence for autonomic contraction of skeletal muscle. Neuroscience 265:9-20
Knox, Christopher J; Hohman, Marc H; Kleiss, Ingrid J et al. (2013) Facial nerve repair: fibrin adhesive coaptation versus epineurial suture repair in a rodent model. Laryngoscope 123:1618-21

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