The brain's cognitive functions derive from the coordinated interactions of large numbers of neurons that are widely distributed throughout the brain. Although seizure activity can be driven by hyperexcitable oscillatory networks, these transient synchronizations of neuronal discharges appear also to be involved in memory consolidation. Thus, a fundamental, yet unresolved, question is how this finely-tuned coordination of activity is achieved. We propose to use a multidisciplinary approach to study a new experimental genetic model of epilepsy in which seizures and enhanced cognition co-exist. This study will help to define the molecular and cellular mechanisms underlying both memory formation and brain rhythmicity. In addition, it could lead to the development of new treatments for conditions associated with memory loss such as aging, Alzheimer's disease, and Huntington's disease, all conditions where PKR activity is abnormally elevated and GABAergic synaptic transmission is altered.
Although some seizure disorders have been associated with extraordinary mental abilities, little is known about the causes or possible genetic mutations associated with this type of epilepsy. We propose to use a multidisciplinary approach to study a new experimental genetic model of epilepsy in which seizures and enhanced cognition co-exists. This study will help to define the common mechanisms underlying memory formation and seizure disorders and may lead to treatments for some major cognitive disorders such as aging, Huntington's disease, and Alzheimer's disease, all conditions where PKR activity and inhibitory synaptic transmission are altered.
|Zhu, Ping Jun; Chen, Chien-Ju; Mays, Jacqunae et al. (2018) mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors. Nat Neurosci 21:799-802|
|Buffington, Shelly A; Di Prisco, Gonzalo Viana; Auchtung, Thomas A et al. (2016) Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring. Cell 165:1762-1775|
|Johnson, Jennifer L; Huang, Wei; Roman, Gregg et al. (2015) TORC2: a novel target for treating age-associated memory impairment. Sci Rep 5:15193|
|Huber, Kimberly M; Klann, Eric; Costa-Mattioli, Mauro et al. (2015) Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism. J Neurosci 35:13836-42|
|Pitcher, Meagan R; Herrera, José A; Buffington, Shelly A et al. (2015) Rett syndrome like phenotypes in the R255X Mecp2 mutant mouse are rescued by MECP2 transgene. Hum Mol Genet 24:2662-72|
|Di Prisco, Gonzalo Viana; Huang, Wei; Buffington, Shelly A et al. (2014) Translational control of mGluR-dependent long-term depression and object-place learning by eIF2?. Nat Neurosci 17:1073-82|
|Buffington, Shelly A; Huang, Wei; Costa-Mattioli, Mauro (2014) Translational control in synaptic plasticity and cognitive dysfunction. Annu Rev Neurosci 37:17-38|
|Meng, Linyan; Person, Richard Erwin; Huang, Wei et al. (2013) Truncation of Ube3a-ATS unsilences paternal Ube3a and ameliorates behavioral defects in the Angelman syndrome mouse model. PLoS Genet 9:e1004039|
|Costa-Mattioli, Mauro; Monteggia, Lisa M (2013) mTOR complexes in neurodevelopmental and neuropsychiatric disorders. Nat Neurosci 16:1537-43|
|Huang, Wei; Zhu, Ping Jun; Zhang, Shixing et al. (2013) mTORC2 controls actin polymerization required for consolidation of long-term memory. Nat Neurosci 16:441-8|
Showing the most recent 10 out of 11 publications