Wollmuth, Lonnie P ABSTRACT The trainee (Noele Certain) is a PhD student who is starting her 3rd year of graduate training in the Graduate Program in Molecular and Cellular Pharmacology at Stony Brook University. Noele?s long-term goal is to maintain an independent research lab in parallel with a teaching career ? she wants to be a strong role-model and mentor to other underrepresented minorities. I believe my laboratory will provide the necessary environment for Noele to achieve her career goals. Specifically, my laboratory and its surroundings will provide Noele with a strong intellectual and technical environment; she will study scientific issues of great clinical importance (structure/function and cell biology of AMPA receptors); she will obtain rigorous training ? an issue of fundamental importance for any scientist; she will be given guidance but also considerable freedom so that she can develop and mature as an independent scientist; she will be given numerous opportunities to present her data in public forums, both locally and nationally; and finally she will be given opportunities to teach undergraand mentor undergraduates under my guidance. With a rigorous but broad background in molecular and cellular pharmacology, Noele will be well prepared to pursue her goal of a research career and to research any topic that may be appropriate as she develops her own research lab. In addition, she will be well placed to act as a mentor for undergraduate and graduate students including underrepresented minorities. Page 1

Public Health Relevance

Wollmuth, Lonnie P PROJECT NARRATIVE This minority supplement is for support of Noele Certain, a graduate student in the Program in Molecular and Cellular Pharmacology at Stony Brook University. Noele is of Native American and West Indian heritage (see Signed Eligibility Letter). She has a career goal of running an NIH-funded research lab and mentoring undergraduate and graduate students. As PI of the parent grant, I will be Noele?s mentor as outlined in the Training Plan and associated documents. Page 1

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
3R01NS088479-06S1
Application #
10007283
Study Section
Biophysics of Neural Systems Study Section (BPNS)
Program Officer
Silberberg, Shai D
Project Start
2015-04-01
Project End
2024-03-31
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Neurosciences
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Wollmuth, Lonnie P (2018) Ion permeation in ionotropic glutamate receptors: Still dynamic after all these years. Curr Opin Physiol 2:36-41
Hansen, Kasper B; Yi, Feng; Perszyk, Riley E et al. (2018) Structure, function, and allosteric modulation of NMDA receptors. J Gen Physiol 150:1081-1105
Amin, Johansen B; Leng, Xiaoling; Gochman, Aaron et al. (2018) A conserved glycine harboring disease-associated mutations permits NMDA receptor slow deactivation and high Ca2+ permeability. Nat Commun 9:3748
Amin, Johansen B; Salussolia, Catherine L; Chan, Kelvin et al. (2017) Divergent roles of a peripheral transmembrane segment in AMPA and NMDA receptors. J Gen Physiol 149:661-680
Zhou, Huan-Xiang; Wollmuth, Lonnie P (2017) Advancing NMDA Receptor Physiology by Integrating Multiple Approaches. Trends Neurosci 40:129-137
Alsaloum, Matthew; Kazi, Rashek; Gan, Quan et al. (2016) A Molecular Determinant of Subtype-Specific Desensitization in Ionotropic Glutamate Receptors. J Neurosci 36:2617-22
Gan, Quan; Dai, Jian; Zhou, Huan-Xiang et al. (2016) The Transmembrane Domain Mediates Tetramerization of ?-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors. J Biol Chem 291:6595-606
Dai, Jian; Wollmuth, Lonnie P; Zhou, Huan-Xiang (2015) Mechanism-Based Mathematical Model for Gating of Ionotropic Glutamate Receptors. J Phys Chem B 119:10934-40