Involuntary muscle activity (spasms) is the most debilitating aspect of spasticity after spinal cord injury (SCI) because the contractions interfere with everyday tasks, and limit rehabilitation. Treatments are not always effective, lowering health- related quality of life. Our long-term Objective is to use closed-loop control of tendon vibration to implement clinically meaningful management of muscle spasms, and to understand the spinal circuits responsible for spasm generation. Specifically, we aim to build on our existing capabilities and collaborations to: 1a) Refine the design of the housing in our wearable device to deliver vibration to the Achilles tendon by using consumer-oriented input; 1b) Determine the vibration parameters that reduce spasms in leg muscles paralyzed by SCI in the laboratory using the wearable device. In either a seated or reclined position, spasms will be detected using electromyography (EMG), then the Achilles tendon will be vibrated at different frequencies, durations and amplitudes to dampen the spasms in real-time using closed-loop control; 2) Examine the efficacy of tendon vibration in altering muscle spasms by treating spasms as they occur, which personalizes the intervention for maximal clinical and user impact. The acute (chronic) effects of vibration on spasms will be evaluated during 24-hour EMG recordings by comparing unconditioned to conditioned spasms at baseline, during the vibration intervention, and post intervention. Pre/Post measures of different aspects of spasticity will provide insight into the site(s), magnitude, and time-course of changes that occur with vibration; and user perspective on the effects of the therapy. Combining the power of non-invasive physiological recordings with functional, clinical and participant reported outcomes will also reveal neural and muscular plasticity, the mechanisms underlying the action of vibration on spasms, and importantly, the rationale to improve this novel approach to spasm management after SCI and other neurological disorders. Many individuals with SCI may find non-pharmacological treatment for spasms attractive because it may lead to reductions or elimination of spasm medications.

Public Health Relevance

PROGRAM NARRATIVE Involuntary muscle activity (spasms) is the most debilitating aspect of spasticity after spinal cord injury because the contractions interfere with everyday tasks, and limit rehabilitation. Use of closed-loop control of tendon vibration to dampen muscle spasms as they occur will personalize this non-pharmacological treatment for maximal clinical and user benefit, and may reduce use of anti-spasm medication. The combination of non-invasive physiological recordings with functional, clinical and participant-reported outcomes of spasticiy will reveal the mechanisms underlying the action of vibration on spasms, and importantly, the rationale to improve this novel approach to spasm management after spinal cord injury and other neurological disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
7R01NS100810-03
Application #
9969165
Study Section
Musculoskeletal Rehabilitation Sciences Study Section (MRS)
Program Officer
Bambrick, Linda Louise
Project Start
2019-01-01
Project End
2022-12-31
Budget Start
2019-07-01
Budget End
2019-12-31
Support Year
3
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Rehabilitation Institute of Chicago D/B/A Shirley Ryan Abilitylab
Department
Type
DUNS #
068477546
City
Chicago
State
IL
Country
United States
Zip Code
60611