Repeat concussions are a growing concern for adolescents and young adult athletes. Experimentally one of the problems is that no one has been addressing this in an ?athlete? model. Growing evidence shows that the brains of those that exercise regularly (athletes) are very different than those that are sedentary. These differences will affect how the ?athlete brain? responds to concussive injuries. In this application we have developed a rathlete model to study the effects of concussive injuries and recovery between the athlete brain and non-athlete brain in both male and female rats. This work will not only provide important information regarding brain injury research, but emphasize the role of exercise in adolescent health.

Public Health Relevance

Repeat concussions are a growing concern for adolescents and young adult athletes, but current experimental research does not include an ?athlete? model when assessing responses to concussions. In this application a rat athlete model is used to study the concussive recovery between males and female ?rathletes? and determine when is the optimal time to resume physical activity after concussive injuries. This work will not only provide important information regarding brain injury research, but emphasize the role of exercise in adolescent health.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS110757-03
Application #
10113685
Study Section
Brain Injury and Neurovascular Pathologies Study Section (BINP)
Program Officer
Kukke, Sahana Nalini
Project Start
2019-03-01
Project End
2024-02-29
Budget Start
2021-03-01
Budget End
2022-02-28
Support Year
3
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Neurosurgery
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095