Physiologically-Based Pharmacokinetic/Clonal Growth

Yang, Raymond S.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute for Occupational Safety and Health (NIOSH)
• Type: Research Project (R01)
• Project #: 5R01OH007556-02
• Application #: 6594401
• Study Section: Special Emphasis Panel (ZOH1-SRC (99))
• Program Officer: Robison, William
• Project Start: 2001-06-01
• Project End: 2004-05-31
• Budget Start: 2002-06-01
• Budget End: 2003-05-31
• Support Year: 2
• Fiscal Year: 2002
• Total Cost: $260,418

Institution

• Name: Colorado State University-Fort Collins
• Department: Public Health & Prev Medicine
• Type: Schools of Veterinary Medicine
• DUNS #: 112617480
• City: Fort Collins
• State: CO
• Country: United States
• Zip Code: 80523

Publications

Lohitnavy, Manupat; Lu, Yasong; Lohitnavy, Ornrat et al. (2008) A possible role of multidrug resistance-associated protein 2 (Mrp2) in hepatic excretion of PCB126, an environmental contaminant: PBPK/PD modeling. Toxicol Sci 104:27-39

Lu, Yasong; Lohitnavy, Manupat; Reddy, Micaela et al. (2008) Quantitative analysis of liver GST-P foci promoted by a chemical mixture of hexachlorobenzene and PCB 126: implication of size-dependent cellular growth kinetics. Arch Toxicol 82:103-16

Yang, Raymond S H; Dennison, James E (2007) Initial analyses of the relationship between ""Thresholds"" of toxicity for individual chemicals and ""Interaction Thresholds"" for chemical mixtures. Toxicol Appl Pharmacol 223:133-8

Lu, Yasong; Lohitnavy, Manupat; Reddy, Micaela B et al. (2006) An updated physiologically based pharmacokinetic model for hexachlorobenzene: incorporation of pathophysiological states following partial hepatectomy and hexachlorobenzene treatment. Toxicol Sci 91:29-41

Mayeno, Arthur N; Yang, Raymond S H; Reisfeld, Brad (2005) Biochemical reaction network modeling: predicting metabolism of organic chemical mixtures. Environ Sci Technol 39:5363-71