Abstract

.- Metalworking fluids (MWF) are complex mixtures widely used in motor vehicle manufacturing, aerospace and a variety of other industries as lubricants and coolants. Human exposure is increasing internationally despite the presence of known carcinogens, such as chlorinated compounds and polycyclic aromatic hydrocarbons in oil-based fluids, and ethanolamines and nitrosamines in water-based fluids. In response to a recommendation by the National Institute of Occupational Safety and Health for reduced exposure limits in 1998, the Occupational Safety and Health Administration added MWF to its list of priority substances for consideration, but formal guidelines were never issued. In 2004, the National Toxicology Program (NIEHS) announced plans for long-term animal testing of MWF to help address lingering uncertainty regarding the carcinogenic risk posed by ongoing exposures.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute for Occupational Safety and Health (NIOSH)
Type
Research Project (R01)
Project #
5R01OH008927-03
Application #
7657377
Study Section
Safety and Occupational Health Study Section (SOH)
Program Officer
Karr, Joan
Project Start
2007-08-01
Project End
2011-07-31
Budget Start
2009-08-01
Budget End
2011-07-31
Support Year
3
Fiscal Year
2009
Total Cost
$380,000
Indirect Cost

  Institution

Name
University of California Berkeley
Department
Type
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704

  Publications

Costello, Sadie; Picciotto, Sally; Rehkopf, David H et al. (2015) Social disparities in heart disease risk and survivor bias among autoworkers: an examination based on survival models and g-estimation. Occup Environ Med 72:138-44
Picciotto, Sally; Brown, Daniel M; Chevrier, Jonathan et al. (2013) Healthy worker survivor bias: implications of truncating follow-up at employment termination. Occup Environ Med 70:736-42
Costello, Sadie; Garcia, Erika; Hammond, S Katharine et al. (2013) Ischemic heart disease mortality and PM(3.5) in a cohort of autoworkers. Am J Ind Med 56:317-25
Betenia, Nicole; Costello, Sadie; Eisen, Ellen A (2012) Risk of cervical cancer among female autoworkers exposed to metalworking fluids. Scand J Work Environ Health 38:78-83
Friesen, Melissa C; Betenia, Nicole; Costello, Sadie et al. (2012) Metalworking fluid exposure and cancer risk in a retrospective cohort of female autoworkers. Cancer Causes Control 23:1075-82
Chevrier, Jonathan; Picciotto, Sally; Eisen, Ellen A (2012) A comparison of standard methods with g-estimation of accelerated failure-time models to address the healthy-worker survivor effect: application in a cohort of autoworkers exposed to metalworking fluids. Epidemiology 23:212-9
Friesen, Melissa C; Costello, Sadie; Thurston, Sally W et al. (2011) Distinguishing the common components of oil- and water-based metalworking fluids for assessment of cancer incidence risk in autoworkers. Am J Ind Med 54:450-60
Costello, Sadie; Friesen, Melissa C; Christiani, David C et al. (2011) Metalworking fluids and malignant melanoma in autoworkers. Epidemiology 22:90-7
Friesen, Melissa C; Costello, Sadie; Eisen, Ellen A (2009) Quantitative exposure to metalworking fluids and bladder cancer incidence in a cohort of autoworkers. Am J Epidemiol 169:1471-8