This application requests funding for a Competitive Renewal of this project. The fundamental goal of this continuing research is to increase the value of two NHP species for research on the genetic causes of human disease. NHP are increasingly important in efforts to understand the genetic basis of susceptibility to common complex diseases such as atherosclerosis, hypertension, osteo-porosis, diabetes, depression and others. Primates are also used to study susceptibility to infectious diseases such as AIDS. Genomic information, including genetic linkage maps, is a critical component of this research. In this project, additional genetic/genomic information will be generated concerning two of the most commonly used primate species, rhesus macaques (Macaca mulatta) and baboons (Papio hamadryas).
Specific Aim 1 is to add new genetic loci to the developing genetic linkage map of the baboon genome, targeting the ends of chromosomes. This genetic map has already facilitated important new findings, but the mapping of new microsatellite polymorphisms to the ends of each baboon chromosome will significantly improve this valuable research tool.
Under Specific Aim 2, the investigator will use physical mapping methods fluorescent in situ hybridization (FISH) to confirm that the loci added to the genetic map under Aim 1 are indeed located at chromosome ends.
Specific Aim 3 is to add the same new loci to the developing linkage map of rhesus macaques.
Aim 4 is to construct a linkage map of the baboon X-chromosome. Completion of these four aims will create new genomic information that will immediately make these two species more useful for the mapping and identification of genes that influence common human diseases such as atherosclerosis, hypertension, osteoporosis, and infection by various viruses.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
2R01RR008781-09
Application #
6472630
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Robinson, Jerry
Project Start
1993-09-30
Project End
2006-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
9
Fiscal Year
2002
Total Cost
$308,000
Indirect Cost
Name
Southwest Foundation for Biomedical Research
Department
Type
DUNS #
City
San Antonio
State
TX
Country
United States
Zip Code
78245
Joganic, Jessica L; Willmore, Katherine E; Richtsmeier, Joan T et al. (2018) Additive genetic variation in the craniofacial skeleton of baboons (genus Papio) and its relationship to body and cranial size. Am J Phys Anthropol 165:269-285
Johnson, Zachary; Brent, Linda; Alvarenga, Juan Carlos et al. (2015) Genetic influences on response to novel objects and dimensions of personality in Papio baboons. Behav Genet 45:215-27
Vinson, A; Curran, J E; Johnson, M P et al. (2011) Genetical genomics of Th1 and Th2 immune response in a baboon model of atherosclerosis risk factors. Atherosclerosis 217:387-94
Vinson, Amanda; Mahaney, Michael C; Diego, Vince P et al. (2008) Genotype-by-diet effects on co-variation in Lp-PLA2 activity and LDL-cholesterol concentration in baboons fed an atherogenic diet. J Lipid Res 49:1295-302
Vinson, A; Mahaney, M C; Cox, L A et al. (2008) A pleiotropic QTL on 2p influences serum Lp-PLA2 activity and LDL cholesterol concentration in a baboon model for the genetics of atherosclerosis risk factors. Atherosclerosis 196:667-73
Bertin, Angeline; Mahaney, Michael C; Cox, Laura A et al. (2007) Quantitative trait loci for peripheral blood cell counts: a study in baboons. Mamm Genome 18:361-72
Raveendran, Muthuswamy; Harris, R Alan; Milosavljevic, Aleksandar et al. (2006) Designing new microsatellite markers for linkage and population genetic analyses in rhesus macaques and other nonhuman primates. Genomics 88:706-10
Dudley, Christopher J; Hubbard, Gene B; Moore, Charleen M et al. (2006) A male baboon (Papio hamadryas) with a mosaic 43,XXY/42,XY karyotype. Am J Med Genet A 140:94-7
Cox, Laura A; Mahaney, Michael C; Vandeberg, John L et al. (2006) A second-generation genetic linkage map of the baboon (Papio hamadryas) genome. Genomics 88:274-81
Havill, L M; Cox, L A; Rogers, J et al. (2005) Cross-species replication of a serum osteocalcin quantitative trait locus on human chromosome 16q in pedigreed baboons. Calcif Tissue Int 77:205-11

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