Our underlying hypothesis is that there are still many more gradient methods to be developed that can not only improve the capabilities of the state-of-the-art technology, but also provide completely new approaches to study molecular structure and dynamics and to optimize the efficiency of the NMR experiment. These new experiments exploit the specific capabilities of gradients to select signals based on their spatial and motional (e.g. flow, diffusion) characteristics.
Our specific aims are:
Aim 1) to design gradient analogues for presently-existing NMR pulse sequences that can improve sensitivity and reduce artifacts, especially in the study of exchanging protons.
Aim 2) to explore the use of pulsed-field-gradient diffusion-weighted NMR experiments for the study of proton and molecular exchange dynamics.
Aim 3) to explore the use of imaging methods for high resolution NMR.
Aim 4) to design selective gradient methods for the detection of so- called multiple spin echoes (MSEs) or multiple-quantum spin echoes (MQEs), which occure when a small magnetic field gradient is present over a sample that has a large magnetization component (generally the solvent).
Aim 5) to design gradient pulse sequences for studying the metabolic and transport properties of viable cells.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
5R01RR011115-05
Application #
6188406
Study Section
Special Emphasis Panel (ZRG7-SSS-7 (33))
Program Officer
Levy, Abraham
Project Start
1996-05-20
Project End
2002-05-18
Budget Start
2000-05-20
Budget End
2002-05-18
Support Year
5
Fiscal Year
2000
Total Cost
$196,673
Indirect Cost
Name
Johns Hopkins University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218