Recent and continuing technological advances are producing large amounts of disparate data about cell structure, function and activity. This is driving the development of tools for storing, mining, analyzing, visualizing and integrating data. This proposal describes the VisANT system: a tool for visual data mining that operates on a local database which includes results from our lab, as well as automatically updated proteomics data from web accessible databases such as MIPS and BIND. In addition to accessing its own database, a name normalization table (i.e. a dictionary of identifiers), permits the system to seamlessly retrieve sequence, disease and other data from sources such as GenBank and OMIM. The visualization tool is able to reversibly group related sets of nodes, and display and duplicate their internal structure, providing an approach to hierarchical representation and modeling. We propose to build further on these unique features by including capabilities for mining and representing chemical reactions, orthologous networks, combinatorially regulated transcriptional networks, splice variants and functional hierarchies. Software is open source, and the system also allows users to exchange and integrate the networks that they discover with those of others. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Research Project (R01)
Project #
5R01RR022971-02
Application #
7457647
Study Section
Special Emphasis Panel (ZRG1-BST-E (51))
Program Officer
Brazhnik, Olga
Project Start
2007-07-01
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
2
Fiscal Year
2008
Total Cost
$437,938
Indirect Cost
Name
Boston University
Department
Genetics
Type
Schools of Engineering
DUNS #
049435266
City
Boston
State
MA
Country
United States
Zip Code
02215
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Linghu, Bolan; Snitkin, Evan S; Hu, Zhenjun et al. (2009) Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network. Genome Biol 10:R91
Hu, Zhenjun; Hung, Jui-Hung; Wang, Yan et al. (2009) VisANT 3.5: multi-scale network visualization, analysis and inference based on the gene ontology. Nucleic Acids Res 37:W115-21
Hu, Zhenjun; Snitkin, Evan S; DeLisi, Charles (2008) VisANT: an integrative framework for networks in systems biology. Brief Bioinform 9:317-25