Older, mechanically ventilated survivors of critical illness are frail and functionally impaired. These deficiencies are a result of critical illness itelf, chronic comorbidities, prolonged bed rest during their acute ICU stay, and their continued care at long term acute care facilities. This leads to inflammation, sarcopenia, malnutrition, chronic anemia and worsening fatigue, weakness and disability. Often, physical rehabilitation is de-escalated in the long term acute care hospital (LTACH) rather than advanced due to these older patients'frailty, multiple comorbidities, chronic disability, impaired mobility, cognitive dysfunction, as well as limited resources. This results in regression of any functional or physical gains achieved in the medical center. We propose a pilot study trialing an 8-week multimodal rehabilitation program (MRP) for older survivors of critical illness who require prolonged mechanical ventilation in a LTACH. This pilot study tests the hypothesis that an MRP that targets functional mobility, strength, endurance and motivation will improve mobility function (gait and balance), and basic activities of daily living (ADLs), by increasing strength and ambulatory capacity and reducing inflammation more than usual rehabilitation care in these patients. The goal is to show that the physical and functional gains made by these older patients enrolled in our MRP will translate into clinically meaningful outcomes, including increased ambulatory capacity, respiratory muscle strength, improved quality of life and better rates of weaning from mechanical ventilation.

Public Health Relevance

We have developed a Multimodal Rehabilitation Program (MRP) which incorporates principles of exercise physiology with physical therapy targeting basic mobility, strength and endurance for older mechanically ventilated survivors of critical illness. We have showed it effective in two initially non-ambulatory ICU survivors, improving their ambulatory capacity (gait speed and 6 minute walk distance), grip strength, and balance and coordination (Short Physical Performance Battery). We propose a pilot study measure the extent to which our novel 8-week MRP compared to usual care on physiologic, clinical and biochemical measures of recovery in debilitated older, survivors of critical illness requiring prolonged mechanical ventilation.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Small Research Grants (R03)
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Special Emphasis Panel (ZAG1-ZIJ-9 (M1))
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Eldadah, Basil A
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University of Maryland Baltimore
Internal Medicine/Medicine
Schools of Medicine
United States
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Verceles, Avelino C; Bhatti, Waqas (2018) The Ethical Concerns of Seeking Consent from Critically Ill, Mechanically Ventilated Patients for Research - A Matter of Possessing Capacity or Surrogate Insight. Clin Ethics 13:107-111
Verceles, Avelino C; Wells, Chris L; Sorkin, John D et al. (2018) A multimodal rehabilitation program for patients with ICU acquired weakness improves ventilator weaning and discharge home. J Crit Care 47:204-210
Verceles, Avelino C; Weiler, Bethany; Koldobskiy, Dafna et al. (2015) Association Between Vitamin D Status and Weaning From Prolonged Mechanical Ventilation in Survivors of Critical Illness. Respir Care 60:1033-9
Verceles, Avelino C; Hager, Erin R (2015) Use of Accelerometry to Monitor Physical Activity in Critically Ill Subjects: A Systematic Review. Respir Care 60:1330-6
Verceles, Avelino C; Corwin, Douglas S; Afshar, Majid et al. (2014) Half of the family members of critically ill patients experience excessive daytime sleepiness. Intensive Care Med 40:1124-31