? While a large body of data exists regarding the short-term quality of life (QOL) following cancer diagnosis and treatment, little is known about the well-being of long-term survivors of adult cancer who are more than three years post-diagnosis; specifically, it is not known whether the impact on QOL that is experienced shortly after diagnosis and treatment persists throughout the life course. This small grant application addresses this gap in the literature by proposing a QOL assessment of these individuals.
The specific aims are to: 1) identify and evaluate the well-being of 400 long-term survivors of adult non-Hodgkin's lymphoma (NHL) (aged 25-90+ years) as evidenced through reported QOL with particular emphasis on psychological distress (as defined by posttraumatic stress disorder; PTSD); and 2) examine the risk and protective factors associated with QOL and PTSD in adult survivors, with a focus on those that can be used for easy screening (e.g., having had multiple types of treatment) and are potentially modifiable (e.g., social support).
These aims are consistent with the recent """"""""Cancer Survivorship Research and Quality of Life Act of 2002"""""""", federal legislation introduced by the Lance Armstrong Foundation and a bipartisan Congressional group to expand research and quality of life programs for cancer survivors. ? ? The study consists of a mailed survey to approximately 900 long-term survivors of adult NHL of varying survival times (3 to 15 years since diagnosis). The survey will assess the QOL and needs of this population, and will incorporate the theoretical base underlying PTSD, a recently considered and promising framework to understand long-term survivors. The results of this study will determine if the QOL of long-term survivors of adult cancer is a cause for concern, and whether services might meet the needs of this growing segment of our population. In addition, findings could lead to the development of interventions that test strategies affecting the risk and protective factors associated with QOL. ? ?

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Research Grants (R03)
Project #
1R03CA101492-01A2
Application #
6839875
Study Section
Special Emphasis Panel (ZCA1-SRRB-Q (M2))
Program Officer
Jeffery, Diana D
Project Start
2004-09-01
Project End
2006-08-31
Budget Start
2004-09-01
Budget End
2005-08-31
Support Year
1
Fiscal Year
2004
Total Cost
$71,108
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Sarker, Shah-Jalal; Smith, Sophia K; Chowdhury, Kashfia et al. (2017) Comparison of the impact of cancer between British and US long-term non-Hodgkin lymphoma survivors. Support Care Cancer 25:739-748
Beaven, Anne W; Samsa, Greg; Zimmerman, Sheryl et al. (2016) Quality of Life is Similar between Long-term Survivors of Indolent and Aggressive Non-Hodgkin Lymphoma. Cancer Invest 34:279-85
Spector, Denise J; Noonan, Devon; Mayer, Deborah K et al. (2015) Are lifestyle behavioral factors associated with health-related quality of life in long-term survivors of non-Hodgkin lymphoma? Cancer 121:3343-51
Bryant, Ashley Leak; Smith, Sophia K; Zimmer, Catherine et al. (2015) An exploratory path model of the relationships between positive and negative adaptation to cancer on quality of life among non-Hodgkin lymphoma survivors. J Psychosoc Oncol 33:310-31
Smith, Sophia K; Samsa, Greg; Ganz, Patricia A et al. (2014) Is there a relationship between posttraumatic stress and growth after a lymphoma diagnosis? Psychooncology 23:315-21
Smith, Sophia K; Mayer, Deborah K; Zimmerman, Sheryl et al. (2013) Quality of life among long-term survivors of non-Hodgkin lymphoma: a follow-up study. J Clin Oncol 31:272-9
Crespi, Catherine M; Ganz, Patricia A; Petersen, Laura et al. (2013) A procedure for obtaining impact of cancer version 2 scores using version 1 responses. Qual Life Res 22:103-9
Leak, Ashley; Smith, Sophia K; Crandell, Jamie et al. (2013) Demographic and disease characteristics associated with non-hodgkin lymphoma survivors' quality of life: does age matter? Oncol Nurs Forum 40:157-62
Oerlemans, Simone; Smith, Sophia K; Crespi, Catherine M et al. (2013) Assessing the impact of cancer among Dutch non-Hodgkin lymphoma survivors compared with their American counterparts: a cross-national study. Psychooncology 22:1258-65
Leak, Ashley; Mayer, Deborah K; Smith, Sophia (2011) Quality of life domains among non-Hodgkin lymphoma survivors: an integrative literature review. Leuk Lymphoma 52:972-85

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