The potential of overdiagnosis and overtreatment of small renal tumors remains a significant concern. It has been estimated that more than 5,000 people per year in the United States alone are having benign renal masses surgically resected. However, there is no ideal method that is clinically applicable or available so far. Limitations stll exist in currently methods for RCC diagnosis, including the invasive renal mass biopsy, highly variable contrast-enhanced computed tomography (CT), magnetic resonance imaging (MRI) and 2-deoxy-2- [18F]fluoro-D-glucose (FDG) positron emission tomography (PET). This proposal aims to develop highly specific PET radiotracers, which are able to provide characteristic biological process information for malignant renal cell carcinoma (RCC) diagnosis. We will develop low-molecular-weight (LMW) agents targeting carbonic anhydrase IX (CA IX), proved to be specifically expressed on clear cell renal cell carcinomas (ccRCCs). We will start with a low potency but very specific peptide ligand. After optimizing its potency and bio-stability we anticipate imaging of ccRCC via LMW [18F] PET tracers, with high binding affinity and specificity, faster normal tissue clearance and less organ uptake. These tracers will also help a broad spectrum of biomedical applications related with tumor hypoxia detection.

Public Health Relevance

The over-expression of carbonic anhydrase IX (CA IX) has been demonstrated in 93-97% of clear cell renal cell carcinomas (ccRCCs) with limited expression in normal tissues/organs. We propose a new series of peptide based low-molecular-weight (LMW) agents can bind to CA IX with high specificity and potency. It will allows the diagnosis malignant RCC, which will greatly help the optimal and personalized therapy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Small Research Grants (R03)
Project #
1R03CA197470-01
Application #
8950115
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Baker, Houston
Project Start
2015-07-01
Project End
2017-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
1
Fiscal Year
2015
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21205
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