Smoking is the leading preventable cause of mortality and morbidity in the United States (CDC 2005). While smoking cessation reduces health risks and disability days, women have more difficulty quitting smoking and available treatments are less successful for women than men. Understanding gender-sensitive risk factors that increase failure to stop smoking is critical for improving interventions. Depression has been identified as a risk factor for smoking, nicotine dependence, smoking cessation failure, and failure to maintain abstinence. Women demonstrate stronger relationships than men between smoking and Major Depression;therefore, depression may exert greater effects on the ability of women to stop smoking. Gender differences in the relationship of depression and smoking behavior have not been thoroughly examined using a longitudinal population-based dataset. For the current project, we are proposing to conduct a detailed investigation into gender differences in the relationship between depression and transitions in smoking and nicotine dependence through a secondary analysis of The National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) Wave 1 (2001-2002, n=43,093) and Wave 2 (2004-2005, n=34,653) databases. The current study will address gaps in research on depression and smoking transitions by examining multiple mood disorders related to smoking behavior (lifetime and current Major Depression, lifetime and current Dysthymia, lifetime Minor Depression), multiple forms of smoking behavior (smoking cessation, smoking relapse, nicotine dependence), and important variables that may mediate the relationship between depression and smoking cessation (stress, control, and social support). The findings of this study will have practical implications for treatment providers and may stimulate research ultimately leading to the development of gender-specific treatments for nicotine dependence.

Public Health Relevance

Although women have a more difficult time quitting smoking, the reasons for this relationship are not well-understood. Women have higher rates of depression and smokers with depression experience difficulty quitting smoking;however, it is unclear to what extent Major Depression, Minor Depression, and Dysthymia negatively impact the ability of smokers to quit smoking and maintain abstinence and to what degree the impact of depression is more pronounced in female smokers than male. The proposed application will examine gender differences in the relationship between depression and ability to quit smoking and avoid smoking relapse.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Small Research Grants (R03)
Project #
1R03DA027052-01A1
Application #
7894249
Study Section
Special Emphasis Panel (ZRG1-RPHB-A (90))
Program Officer
Schulden, Jeffrey D
Project Start
2010-04-01
Project End
2012-03-31
Budget Start
2010-04-01
Budget End
2011-03-31
Support Year
1
Fiscal Year
2010
Total Cost
$70,750
Indirect Cost
Name
Yale University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Weinberger, Andrea H; Pilver, Corey E; Mazure, Carolyn M et al. (2014) Stability of smoking status in the US population: a longitudinal investigation. Addiction 109:1541-53
Weinberger, Andrea H; Mazure, Carolyn M; McKee, Sherry A et al. (2014) The Association of Tobacco Use and Gender to Cardiac Rehabilitation Outcomes: A Preliminary Investigation. J Subst Use 19:171-175
Weinberger, Andrea H; Mazure, Carolyn M; Morlett, Alejandra et al. (2013) Two decades of smoking cessation treatment research on smokers with depression: 1990-2010. Nicotine Tob Res 15:1014-31
Weinberger, Andrea H; Pilver, Corey E; Hoff, Rani A et al. (2013) Changes in smoking for adults with and without alcohol and drug use disorders: longitudinal evaluation in the US population. Am J Drug Alcohol Abuse 39:186-93
Weinberger, Andrea H; Pilver, Corey E; Desai, Rani A et al. (2013) The relationship of dysthymia, minor depression, and gender to changes in smoking for current and former smokers: longitudinal evaluation in the U.S. population. Drug Alcohol Depend 127:170-6
Crane, Cory A; Hawes, Samuel W; Weinberger, Andrea H (2013) Intimate partner violence victimization and cigarette smoking: a meta-analytic review. Trauma Violence Abuse 14:305-15
McKee, Sherry A; Weinberger, Andrea H (2013) How can we use our knowledge of alcohol-tobacco interactions to reduce alcohol use? Annu Rev Clin Psychol 9:649-74
Weinberger, Andrea H; McKee, Sherry A (2012) Mood and smoking behavior: the role of expectancy accessibility and gender. Addict Behav 37:1349-52
Mackowick, Kristen M; Lynch, Marie-Josee; Weinberger, Andrea H et al. (2012) Treatment of tobacco dependence in people with mental health and addictive disorders. Curr Psychiatry Rep 14:478-85
Weinberger, Andrea H; Pilver, Corey E; Desai, Rani A et al. (2012) The relationship of major depressive disorder and gender to changes in smoking for current and former smokers: longitudinal evaluation in the US population. Addiction 107:1847-56