Exposure to opioid analgesics during medical care is a key driver of the opioid epidemic. Such exposures are widespread. Reducing clinical opioid exposures is crucial for the prevention of drug abuse. Yet opioids remain essential first-line agents in treating pain, and it remains vital that pain be appropriately managed. Non-opioid pain treatments help to resolve the opioid/pain conflict. This project will examine the opioid-sparing and pain-relieving potential of a novel, non-pharmacological treatment for pain. Recent pre-clinical work has identified an anti-nociceptive effect of green light. Visually- mediated cognitive and biological effects of specific color-ranges of light are broadly recognized in areas of affect and circadian rhythm. Similar effects on pain perception are less understood. We will conduct a pilot trial of the potential for green-spectrum light exposure as an opioid-sparing analgesic adjunct.

Public Health Relevance

We will conduct a pilot trial testing the potential opioid-sparing analgesic effect of a novel non-pharmacological treatment which uses commodity eyeglasses to modify the visualized light spectrum. Preclinical findings have shown such treatments to alter pain perception. Our overall goal is to reduce opioid exposures in clinical care.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Small Research Grants (R03)
Project #
5R03DA046011-02
Application #
9912143
Study Section
Interventions to Prevent and Treat Addictions Study Section (IPTA)
Program Officer
Foster, Katrina L
Project Start
2019-04-15
Project End
2021-03-31
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
2
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Duke University
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705