Hearing loss impairs speech perception and loudness perception, which can have negative effects on academic achievement, cognition, and social functioning. Many aspects of deteriorated hearing performance, such as listening to speech in a complex acoustic background, cannot be explained solely on the basis of peripheral damage. Performance on these tasks is likely affected by neural reorganization or deterioration in the central auditory pathway. The long-term goal of our research program is to investigate how acquired hearing loss affects synaptic organization of the auditory system, how these synaptic changes relate to behavioral changes in hearing, and whether or not the synaptic abnormalities can be recovered or prevented. It is important that we investigate the impact of different forms of hearing loss on the brain to understand variable perceptual deficits and unpredictable outcomes after hearing intervention. This grant will support functional and anatomical investigations in mice with noise-induced hearing damage. Mice will be exposed to moderate noise that has been historically characterized as safe and to moderately loud noise known to cause permanent hearing loss. We will measure behavioral changes in temporal processing and loudness perception and investigate the corresponding changes in structure and organization of neural inputs to specific cell types in the ventral cochlear nucleus. These studies will provide important information for understanding complex hearing deficits and may have implications for improving treatment of hearing loss and for noise trauma prevention guidelines.

Public Health Relevance

Alterations in auditory brain structures associated with hearing loss may be correlated with sound perception deficits that cannot be explained solely on the basis of inner ear damage, such as difficulty understanding speech when multiple people are talking simultaneously. We need to understand how the brain changes with hearing loss so we can improve hearing loss treatment and prevent undesirable changes in how the brain processes sound. This project investigates the effects of noise-induced hearing loss on the brain, and how hearing loss-related changes to the brain relate to perceptual difficulties.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Small Research Grants (R03)
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Communication Disorders Review Committee (CDRC)
Program Officer
Cyr, Janet
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Johns Hopkins University
Schools of Medicine
United States
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Lauer, Amanda M; Behrens, Derik; Klump, Georg (2017) Acoustic startle modification as a tool for evaluating auditory function of the mouse: Progress, pitfalls, and potential. Neurosci Biobehav Rev 77:194-208
Lauer, Amanda M (2017) Minimal Effects of Age and Exposure to a Noisy Environment on Hearing in Alpha9 Nicotinic Receptor Knockout Mice. Front Neurosci 11:304
Sun, Daniel Q; Lehar, Mohamed; Dai, Chenkai et al. (2015) Histopathologic Changes of the Inner ear in Rhesus Monkeys After Intratympanic Gentamicin Injection and Vestibular Prosthesis Electrode Array Implantation. J Assoc Res Otolaryngol 16:373-87
McGuire, Brian; Fiorillo, Benjamin; Ryugo, David K et al. (2015) Auditory nerve synapses persist in ventral cochlear nucleus long after loss of acoustic input in mice with early-onset progressive hearing loss. Brain Res 1605:22-30
Ngodup, Tenzin; Goetz, Jack A; McGuire, Brian C et al. (2015) Activity-dependent, homeostatic regulation of neurotransmitter release from auditory nerve fibers. Proc Natl Acad Sci U S A 112:6479-84
Hiebler, Shandi; Masuda, Tomohiro; Hacia, Joseph G et al. (2014) The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder. Mol Genet Metab 111:522-532
Lauer, Amanda M; Connelly, Catherine J; Graham, Heather et al. (2013) Morphological characterization of bushy cells and their inputs in the laboratory mouse (Mus musculus) anteroventral cochlear nucleus. PLoS One 8:e73308
Schettino, Amy E; Lauer, Amanda M (2013) The efficiency of design-based stereology in estimating spiral ganglion populations in mice. Hear Res 304:153-8