Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Small Research Grants (R03)
Project #
1R03DE011844-01
Application #
2133220
Study Section
Special Emphasis Panel (ZDE1-WG (05))
Project Start
1996-06-01
Project End
1998-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Temple University
Department
Physiology
Type
Schools of Medicine
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Brando, C; Marcinkiewicz, C; Goldman, B et al. (2000) EC3, a heterodimeric disintegrin from Echis carinatus, inhibits human and murine alpha4 integrin and attenuates lymphocyte infiltration of Langerhans islets in pancreas and salivary glands in nonobese diabetic mice. Biochem Biophys Res Commun 267:413-7
Marcinkiewicz, C; Calvete, J J; Marcinkiewicz, M M et al. (1999) EC3, a novel heterodimeric disintegrin from Echis carinatus venom, inhibits alpha4 and alpha5 integrins in an RGD-independent manner. J Biol Chem 274:12468-73
Danen, E H; Marcinkiewicz, C; Cornelissen, I M et al. (1998) The disintegrin eristostatin interferes with integrin alpha 4 beta 1 function and with experimental metastasis of human melanoma cells. Exp Cell Res 238:188-96
McLane, M A; Marcinkiewicz, C; Vijay-Kumar, S et al. (1998) Viper venom disintegrins and related molecules. Proc Soc Exp Biol Med 219:109-19