This is a revised proposal to conduct a prospective cohort study of the effects of Type II diabetes on an array of oral health diseases and parameters in older adults. A major aim of the study is to compare well-controlled vs. poorly-controlled community dwelling diabetic subjects enrolled in an ongoing study in the University of Michigan s Claude D. Pepper Older Americans Independence Center (OAIC) on oral health and oral parameters over a one-year period. The second major aim is to compare all these diabetic subjects (both well- and poorly-controlled) to an age-, sex-, race-matched group of non-diabetics from the community. These two broad aims are presented as 6 specific aims within the text of the application. The subjects for this proposed oral health study will be drawn from the enrollment lists of the on-going Pepper medical study. An extensive list of inclusion and exclusion criteria will be used to determine subject eligibility for both diabetic and non-diabetic subjects. In the proposed dental study, subjects will receive a standardized comprehensive oral examination and questionnaire. Parotid and whole saliva, gingival plaque, and gingival crevicular fluid samples will be collected for analysis.
| Chavez, E M; Borrell, L N; Taylor, G W et al. (2001) A longitudinal analysis of salivary flow in control subjects and older adults with type 2 diabetes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:166-73 |
| Chavez, E M; Taylor, G W; Borrell, L N et al. (2000) Salivary function and glycemic control in older persons with diabetes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89:305-11 |
| Lin, B P; Taylor, G W; Allen, D J et al. (1999) Dental caries in older adults with diabetes mellitus. Spec Care Dentist 19:8-14 |
