? Individuals with Down syndrome (DS) have mild to moderate mental retardation, short stature and associated overweight. Weight loss interventions for children and adolescents with DS have not been studied sufficiently. With typical children, interventions in which parents are taught to use behavior modification to improve dietary and activity habits have been effective. Research is needed to investigate behavioral weight reduction with a new population, adolescents with DS. This study will compare the effectiveness of: 1) a Parent Supported Weight Reduction intervention (PSWR) that combines behavior modification and nutrition/activity education (NAE), with 2) NAE alone and 3) a Wait List (WL) control group. The primary Specific Aim is to determine whether adolescents with DS in the PSWR condition lose more weight and body fat than participants in NAE alone or WL. Two secondary Specific Aims are to determine whether adolescents in PSWR are more successful than those in NAE alone in: 1) meeting the prescribed number of servings in specified food groups, and 2) increasing physical activity. Seventy-two (72) adolescents with DS between 13-18 who are overweight (body mass index > 95th percentile for age and gender), and their parents, will be randomly assigned to one of three groups: PSWR, NAE-alone or WL. PSWR and NAE-alone groups will receive a 6-month intervention, meeting weekly for 10 wks (90 min sessions), then bi-weekly and monthly. NAE components in both groups will be conducted by a nutrition educator, supervised by a nutritionist/registered dietician and a physical therapist, both with expertise in DS (co-investigators). Behavioral components of PSWR will be conducted by a behavioral psychologist with expertise in DS (the PI). Following the 6-month intervention, participants in PSWR and NAE-alone will be followed over a 6-month maintenance phase. We will measure and compare changes in body fat (BIA), BMI-z score, number of servings in specified food groups, and activity (accelerometer) at pre-intervention, 10 wks, 6 mos (post intervention) and 12 mos (maintenance). Participants in WL will not receive a concurrent intervention, but will participate in BIA and BMI-z measurement at the same intervals. WL participants will be offered the most effective intervention (PSWR or NAE) in Year 2. Our long-term goals with this project are to: 1) learn more about health promotion in families of children with DS and other developmental disabilities, and 2) develop an R01 application to investigate processes associated with long-term behavior change and health, especially adolescent-managed intervention ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Small Research Grants (R03)
Project #
5R03DK070627-02
Application #
7259474
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (M1))
Program Officer
Horlick, Mary
Project Start
2006-07-15
Project End
2010-06-30
Budget Start
2007-07-01
Budget End
2010-06-30
Support Year
2
Fiscal Year
2007
Total Cost
$113,890
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Psychiatry
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Weems, Maresa; Truex, Laura; Scampini, Renee et al. (2017) A Novel Weight-Loss Tool Designed for Adolescents with Intellectual Disabilities. J Acad Nutr Diet 117:1503-1508
Curtin, Carol; Bandini, Linda G; Must, Aviva et al. (2013) Parent support improves weight loss in adolescents and young adults with Down syndrome. J Pediatr 163:1402-8.e1
Fleming, Richard K; Stokes, Elise A; Curtin, Carol et al. (2008) Behavioral Health in Developmental Disabilities: A Comprehensive Program of Nutrition, Exercise, and Weight Reduction. Int J Behav Consult Ther 4:287-296