Abstract

The formation of trophectoderm and the differentiation of trophoblasts are critical steps in the establishment and maintenance of pregnancy. Very little is known about the molecular regulation of this differentiation process. The investigator will test his hypothesis in two specific aims.
Aim 1. To characterize placental HLH protein DNA and protein protein interactions in vitro and in vivo.
Aim 2. To clone trophoblast HLH cDNAs by protein DNA and proteinprotein interactions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
5R03HD036324-02
Application #
6181938
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Program Officer
Yoshinaga, Koji
Project Start
1999-07-01
Project End
2002-06-30
Budget Start
2000-07-01
Budget End
2002-06-30
Support Year
2
Fiscal Year
2000
Total Cost
$61,609
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Veterinary Sciences
Type
Other Domestic Higher Education
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Liu, Yi-Ping; Burleigh, David; Durning, Maureen et al. (2004) Id2 is a primary partner for the E2-2 basic helix-loop-helix transcription factor in the human placenta. Mol Cell Endocrinol 222:83-91