Description) This project proposes to conduct two pilot studies on the hearing and speech intelligibility skills of young males with fragile X syndrome. The specific objectives are to determine if atypical peripheral hearing, auditory brainstem responses, and higher auditory processing skills are displayed in males with fragile X syndrome, and to determine the phonologic, prosodic, segmental, and oral-motor factors that affect the speech intelligibility of young males with fragile X syndrome. In Study 1, the investigators hypothesize that males with fragile X syndrome, compared to typically developing controls, will display normal peripheral and brainstem measures of hearing, and will show poorer higher auditory processing for recognizing speech in noise than in quiet. In Study II, the investigators hypothesize that males with fragile X syndrome will show poorer speech intelligibility in conversational speech due to phonological errors, prosodic features, segmental features, and oral-motor skills.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
5R03HD040640-02
Application #
6536370
Study Section
Special Emphasis Panel (ZHD1-MRG-C (15))
Program Officer
Oster-Granite, Mary Lou
Project Start
2001-05-01
Project End
2003-10-31
Budget Start
2002-05-01
Budget End
2003-10-31
Support Year
2
Fiscal Year
2002
Total Cost
$72,750
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pediatrics
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Estigarribia, Bruno; Martin, Gary E; Roberts, Joanne E (2012) Cognitive, environmental, and linguistic predictors of syntax in fragile X syndrome and Down syndrome. J Speech Lang Hear Res 55:1600-12
Estigarribia, Bruno; Martin, Gary E; Roberts, Joanne E et al. (2011) Narrative Skill in Boys with Fragile X Syndrome with and without Autism Spectrum Disorder. Appl Psycholinguist 32:359-388
Estigarribia, Bruno; Erwick Roberts, Joanne; Sideris, John et al. (2010) Expressive morphosyntax in boys with Fragile X syndrome with and without autism spectrum disorder. Int J Lang Commun Disord :
Barnes, Elizabeth; Roberts, Joanne; Long, Steven H et al. (2009) Phonological accuracy and intelligibility in connected speech of boys with fragile X syndrome or Down syndrome. J Speech Lang Hear Res 52:1048-61
Zajac, David J; Harris, Adrianne A; Roberts, Joanne E et al. (2009) Direct magnitude estimation of articulation rate in boys with fragile X syndrome. J Speech Lang Hear Res 52:1370-9
Price, Johanna R; Roberts, Joanne E; Hennon, Elizabeth A et al. (2008) Syntactic complexity during conversation of boys with fragile X syndrome and Down syndrome. J Speech Lang Hear Res 51:3-15
Roberts, Joanne; Martin, Gary E; Moskowitz, Lauren et al. (2007) Discourse skills of boys with fragile X syndrome in comparison to boys with Down syndrome. J Speech Lang Hear Res 50:475-92
Roberts, Joanne E; Hennon, Elizabeth A; Price, Johanna R et al. (2007) Expressive language during conversational speech in boys with fragile X syndrome. Am J Ment Retard 112:1-17
Roberts, Joanne; Price, Johanna; Barnes, Elizabeth et al. (2007) Receptive vocabulary, expressive vocabulary, and speech production of boys with fragile X syndrome in comparison to boys with down syndrome. Am J Ment Retard 112:177-93
Roberts, Joanne E; Price, Johanna; Malkin, Cheryl (2007) Language and communication development in Down syndrome. Ment Retard Dev Disabil Res Rev 13:26-35

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