Disadvantaged social context, especially poverty, is associated with well-documented negative consequences for children and adolescents in the United States. Poverty is correlated with dropping out of school, low academic achievement, teenage pregnancy and childbearing, poor mental and physical health, delinquent behavior, and unemployment in early adulthood. In this application, while continuing this tradition of poverty research, we attempt to illuminate one essential mechanism between poverty and adolescent outcomes. We investigate how social and demographic contexts affect the expression of heritability for a variety of educational and behavior outcomes among adolescents in the United States. We test the hypothesis that advantaged social context generally boosts and disadvantaged social context generally suppresses genetic potential for educational outcomes. Our measures of educational outcomes include college plan, grade point average, the first grade retention, high school graduation, and college attendance. Our second hypothesis concerns deviant behavior. We test the hypothesis that when adolescents have behavior choices, genetic expression will be greater, and when they do not have choices, either through social controls or through impoverished environments that do not provide a range of choices, the genetic expression will be reduced. We measure deviant behavior by smoking, drinking, drug use, delinquency, violence, and aggression. The hypotheses will be tested by estimating heritability for different social and demographic contexts using sibling data from four waves of the Add Health Study carried out in 1994, 1995, 1996, and 2000 and employing Pearson's correlation analysis, structural equation models, and the mixed models.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
5R03HD042490-02
Application #
6629446
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Evans, V Jeffrey
Project Start
2002-07-01
Project End
2006-06-30
Budget Start
2003-07-01
Budget End
2006-06-30
Support Year
2
Fiscal Year
2003
Total Cost
$71,269
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Miscellaneous
Type
Schools of Public Health
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Guo, Guang; Li, Yi; Wang, Hongyu et al. (2015) Peer Influence, Genetic Propensity, and Binge Drinking: A Natural Experiment and a Replication. AJS 121:914-54
Guo, Guang; Fu, Yilan; Lee, Hedwig et al. (2014) Genetic bio-ancestry and social construction of racial classification in social surveys in the contemporary United States. Demography 51:141-72
Guo, Guang; Cai, Tianji; Guo, Rui et al. (2010) The dopamine transporter gene, a spectrum of most common risky behaviors, and the legal status of the behaviors. PLoS One 5:e9352
Guo, Guang; Ou, Xiao-Ming; Roettger, Michael et al. (2008) The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity. Eur J Hum Genet 16:626-34
Guo, Guang; Wilhelmsen, Kirk; Hamilton, Nathan (2007) Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes. Am J Med Genet B Neuropsychiatr Genet 144B:417-23
Guo, Guang; North, Kari E; Gorden-Larsen, Penny et al. (2007) Body mass, DRD4, physical activity, sedentary behavior, and family socioeconomic status: the add health study. Obesity (Silver Spring) 15:1199-206
Guo, Guang; Tong, Yuying; Xie, Cui-Wei et al. (2007) Dopamine transporter, gender, and number of sexual partners among young adults. Eur J Hum Genet 15:279-87
Guo, Guang; Roettger, Michael E; Shih, Jean C (2007) Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults. Hum Genet 121:125-36
Guo, Guang (2006) Genetic similarity shared by best friends among adolescents. Twin Res Hum Genet 9:113-21
Guo, Guang; North, Kari; Choi, Seulki (2006) DRD4 gene variant associated with body mass: the National Longitudinal Study of Adolescent Health. Hum Mutat 27:236-41

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