The present research is aimed at better understanding the """"""""conversation"""""""" between """"""""affective"""""""" and """"""""cognitive"""""""" processes that initiates in adolescence. Described below are a series of longitudinal studies that will examine the structure and function of a specific neural system in the developing brain. Structural and functional MR, as well as behavioral measures will be applied to this issue. It is the goal of this work to bring convergent imaging technologies to bear on the relation of brain and mind in the developing adolescent. The current project is directed at understanding the development of the functional connectivity between medial temporal lobe structures, and frontal cortex. It is hypothesized that maturation of these reciprocal projections may be associated with increased cognitive ability, as well as significant improvements in affective competencies and emotional regulation. The maturation of these circuits is believed to be essential for the behavioral milestones required for a successful transition from childhood to adulthood. It is additionally hypothesized that specific types of psychopathology may be associated with perturbation of this developmental sequence. There are three phases to the proposed project that serve to mutually inform one another. Structural MR imagining (both high resolution structural imaging and diffusion tensor imaging), functional neuroimaging, and behavioral measures will be collected from a group of adolescent subjects longitudinally during their adolescence. The investigator will examine the relationships among functional anatomy, morphology, and behavioral performance on cognitive and affective challenge paradigms. Through the acquisition of longitudinal data the investigator hopes to establish correlates which typify neurobiological changes associated with this period of development.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
5R03HD045742-02
Application #
7024502
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Freund, Lisa S
Project Start
2005-03-01
Project End
2006-06-30
Budget Start
2006-03-01
Budget End
2006-06-30
Support Year
2
Fiscal Year
2006
Total Cost
$42,571
Indirect Cost
Name
Dartmouth College
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Baird, Abigail A; Silver, Shari H; Veague, Heather B (2010) Cognitive control reduces sensitivity to relational aggression among adolescent girls. Soc Neurosci 5:519-32
Bennett, Craig M; Baird, Abigail A (2006) Anatomical changes in the emerging adult brain: a voxel-based morphometry study. Hum Brain Mapp 27:766-77