Despite substantially declining during the past 2 decades, teenage pregnancy rates remain the highest in the United States compared to other Western countries. Being born to a teenage mother has been noted in the literature and public perceptions for many decades as a permanent source of developmental disadvantages for children. Although a strong body of literature has compared children of teen mothers to children of older mothers, less known are factors contributing to variations in developmental outcomes among children of teen mothers. As such, the relevant knowledge base is limited in informing prevention programming for healthy development among children of teen mothers. Capitalizing on unique longitudinal studies of teen mothers and their children, the proposed study aims to remedy these gaps with an explicit focus on and in-depth investigation of maternal history of substance use and exposure to adverse childhood experiences (ACEs) as two key factors promoting within-group variability in children of teen mothers. Specifically, first, we will investigate whether the timing and longitudinal trajectories of teen mothers? substance use beyond the prenatal period affect child developmental outcomes. Second, we will examine whether maternal ACEs, which are intergenerational risk factors preceding the child?s birth, influence child development and intersect with a more proximal maternal risk factor, maternal substance use. The proposed study will leverage access to existing two-cohort Young Women and Child Development Study (YCDS) panels. Cohort 1 (C1, n = 240) spans 17 years of both the mothers? and child?s life course. At the last wave of cohort 1data collection, children were 17 years old and mothers were 33.8 years old on average. Cohort 2 (C2, n = 255) encompasses 14 years of both mothers? and child?s life course. At the last wave of cohort 2 data collection, children were 13.5 years old and mothers were 30.3 years old on average. This rich dataset has all the key elements to achieve the aims of the proposed study, including (a) prospective and repeated assessment of child development from infancy through adolescence in both cohorts using validated assessment packages spanning child executive functioning, language development, externalizing behaviors, and other developmental measures; (b) annual or semiannual assessments of maternal substance use from pregnancy to 17 years postpartum in C1 and 13.5 years postpartum in C2; and (c) assessment of maternal ACEs. The comprehensiveness of the datasets, with 14 to 17 waves of annual assessment, offers a novel opportunity to use longitudinal modeling strategies to identify the developmental timing and dynamic changes in maternal substance use among pregnant women, link them to child developmental outcomes, and then link those back to maternal ACEs exposure. The proposed study will maximize the use of data from both cohorts by adopting a cross-validation strategy and an integrated strategy of combining data with tests of cohort effect.

Public Health Relevance

Proposed analyses will enable us to identify alternative strategic points for intervening in maternal substance use in addition to the prenatal period, further enhancing the public health system?s capacity to interrupt intergenerational risk processes contributing to disparities in child developmental outcomes. Establishing additional intervention points is particularly important for low-income pregnant women and their children, who are more likely to receive late, inadequate, or no prenatal care compared to their older or high-income counterparts. Further, results from the proposed study may inform a shift in pediatric settings to a multigenerational approach that accounts for maternal history of childhood trauma and adds a screening on maternal adverse childhood experiences and substance use to the current American Academy of Pediatrics recommendations for preventive pediatric health care.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Small Research Grants (R03)
Project #
5R03HD097379-02
Application #
9789683
Study Section
National Institute of Child Health and Human Development Initial Review Group (CHHD)
Program Officer
Esposito, Layla E
Project Start
2018-09-20
Project End
2020-08-31
Budget Start
2019-09-01
Budget End
2020-08-31
Support Year
2
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
University-Wide
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089