We request support to perform data analyses in the NAS-NRC Twin Registry using state-of-the-art statistical methodologies. The registry is the largest existing in the United States and is the only registry for which longitudinal data are available. This resource is currently underutilized, and only a limited number of publications have addressed issues relevant to cardiovascular epidemiology. Given recent advances in statistical methods for twin data, this resource represents a unique opportunity to address timely issues pertinent to the role of genetic and environmental factors in the manifestation of cardiovascular disease and related risk factors. The planned analyses will expand, confirm, and cross-validate related findings in the NHLBI Twin Study, which is only a small subset of the registry. Specific objectives of this proposal are: (1) To determine the extent to which an increased familial risk in CVD mortality among twins is mediated by similarities in behavioral risk factors such as smoking, food habits, changes in weight since induction, physical activity, and socioeconomic variables. (2) To assess the contribution of genetic and environmental factors to twin similarities in health behaviors. (3) To investigate the genetic determinants in the continuity or discontinuity of health behaviors in adult life (e.g., smoking cessation, weight gain). We expect at least four publications to result from these analyses.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Small Research Grants (R03)
Project #
Application #
Study Section
Special Emphasis Panel (SRC (OH))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Sri International
Menlo Park
United States
Zip Code
Carmelli, D; Swan, G E; Cardon, L R (1995) Genetic mediation in the relationship of education to cognitive function in older people. Psychol Aging 10:48-53
Swan, G E; Carmelli, D (1995) Characteristics associated with excessive weight gain after smoking cessation in men. Am J Public Health 85:73-7
Carmelli, D; Selby, J V; Quiroga, J et al. (1994) 16-year incidence of ischemic heart disease in the NHLBI twin study. A classification of subjects into high- and low-risk groups. Ann Epidemiol 4:198-204
Carmelli, D; Robinette, D; Fabsitz, R (1994) Concordance, discordance and prevalence of hypertension in World War II male veteran twins. J Hypertens 12:323-8
Carmelli, D; Cardon, L R; Fabsitz, R (1994) Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments? Am J Hum Genet 55:566-73
Carmelli, D; Heath, A C; Robinette, D (1993) Genetic analysis of drinking behavior in World War II veteran twins. Genet Epidemiol 10:201-13
Carmelli, D; Swan, G E; Robinette, D (1993) The relationship between quitting smoking and changes in drinking in World War II veteran twins. J Subst Abuse 5:103-16
Carmelli, D; Swan, G E; Robinette, D et al. (1992) Genetic influence on smoking--a study of male twins. N Engl J Med 327:829-33