Despite considerable epidemiological and clinical trial data, the link between sodium intake and blood pressure control remains debated and poorly characterized, in part due to the degree of variability inherent in assessing dietary composition. By refining and applying new statistical methodology that addresses measurement errors, we propose to extend the analysis of existing data from the completed Trial of Nonpharmacologic Interventions in the Elderly to characterize relationships between blood pressure control and sodium intake (as measured by 24-hour dietary recalls and 24-hour urine excretion) using models that address the imprecision of these dietary measures; examine clinical and demographic factors that may affect this relationship and, in doing so, further characterize relative sodium sensitivity among a cohort of hypertensives; characterize the relationships between the intakes of other dietary factors (calcium, potassium, and magnesium) with blood pressure control; and examine the relationship between pharmacologic and dietary control of blood pressure among individuals prior to weaning from, and after resumption of, antihypertensive medications. Secondary aims include the application and further development of longitudinal measurement-error models for use in analyzing serial dietary data. The team of investigators for this project are well-qualified to conduct this scientific investigation, were instrumental in developing the TONE database, and have excellent resources.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Small Research Grants (R03)
Project #
1R03HL060197-01
Application #
2603736
Study Section
Clinical Trials Review Committee (CLTR)
Project Start
1998-04-01
Project End
2000-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Kostis, William J; Cabrera, Javier; Hooper, W Craig et al. (2013) Relationships between selected gene polymorphisms and blood pressure sensitivity to weight loss in elderly persons with hypertension. Hypertension 61:857-63
Lee, Kathleen A; Gong, Michelle N (2011) Pre-B-cell colony-enhancing factor and its clinical correlates with acute lung injury and sepsis. Chest 140:382-390
Gong, M N; Bajwa, E K; Thompson, B T et al. (2010) Body mass index is associated with the development of acute respiratory distress syndrome. Thorax 65:44-50
Gong, Michelle N (2009) Gene association studies in acute lung injury: replication and future direction. Am J Physiol Lung Cell Mol Physiol 296:L711-2
Espeland, Mark A; Evans, Greg W; Wagenknecht, Lynne E et al. (2003) Site-specific progression of carotid artery intimal-medial thickness. Atherosclerosis 171:137-43
Espeland, Mark A; Kumanyika, Shiriki; Yunis, Carla et al. (2002) Electrolyte intake and nonpharmacologic blood pressure control. Ann Epidemiol 12:587-95
Kostis, John B; Wilson, Alan C; Shindler, Daniel M et al. (2002) Persistence of normotension after discontinuation of lifestyle intervention in the trial of TONE. Trial of Nonpharmacologic Interventions in the Elderly. Am J Hypertens 15:732-4
Kumanyika, Shiriki K; Espeland, Mark A; Bahnson, Judy L et al. (2002) Ethnic comparison of weight loss in the Trial of Nonpharmacologic Interventions in the Elderly. Obes Res 10:96-106
Espeland, M A; Kumanyika, S; Wilson, A C et al. (2001) Lifestyle interventions influence relative errors in self-reported diet intake of sodium and potassium. Ann Epidemiol 11:85-93
Appel, L J; Espeland, M A; Easter, L et al. (2001) Effects of reduced sodium intake on hypertension control in older individuals: results from the Trial of Nonpharmacologic Interventions in the Elderly (TONE). Arch Intern Med 161:685-93

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