Mechanical loading and especially dynamic loading, is believed to play a major role in degenerative joint diseases. Furthermore, motion (i.e., kinematics) and loading (i.e., contact stresses) often interact to influence disease progression. Thus, knowledge of in vivo joint motion and loading during functional activities would help address this clinically significant issue. While dynamic imaging advances now permit accurate measurement of in vivo joint kinematics, a non-invasive experimental approach does not exist for measuring in vivo joint loading. Consequently, computer simulations have been used to develop predictions given estimates of the muscle forces acting on the joint. However, current rigid body and deformable modeling approaches are not able to calculate contact stress results during movement in critical joints such as the knee. A logical solution to this problem is to incorporate deformable joint models into a larger rigid body dynamic model, thereby obtaining the advantages of both approaches. However, the computation cost of such a hybrid approach is currently a limiting factor. This project therefore proposes the development of a parallel-processing framework for studying human joint mechanics.
The specific aims of the project are as follows: (1) Create a dynamic musculoskeletal model with deformable knee joint contact. Deformable contact in the knee will be studied initially since the knee is the most commonly injured joint. (2) Incorporate this model into a parallel-processing optimization framework. Parallel processing will be used to reduce the computational time for predictive optimizations from weeks to a matters of hours. (3) Evaluate the model's ability to predict experimental movement data. Pre-existing experimental movement data will be used to evaluate the model's ability to predict motion and ultimately joint contact stresses. The resulting functional virtual human model can then be used for basic research and clinical applications.
| Koh, Byung-Il; Reinbolt, Jeffrey A; George, Alan D et al. (2009) Limitations of parallel global optimization for large-scale human movement problems. Med Eng Phys 31:515-21 |
| Fregly, Benjamin J (2009) Design of Optimal Treatments for Neuromusculoskeletal Disorders using Patient-Specific Multibody Dynamic Models. Int J Comput Vis Biomech 2:145-155 |
| Fregly, Benjamin J; Reinbolt, Jeffrey A; Rooney, Kelly L et al. (2007) Design of patient-specific gait modifications for knee osteoarthritis rehabilitation. IEEE Trans Biomed Eng 54:1687-95 |
| Reinbolt, Jeffrey A; Haftka, Raphael T; Chmielewski, Terese L et al. (2007) Are patient-specific joint and inertial parameters necessary for accurate inverse dynamics analyses of gait? IEEE Trans Biomed Eng 54:782-93 |
| Lin, Yi-Chung; Farr, Jack; Carter, Kevin et al. (2006) Response surface optimization for joint contact model evaluation. J Appl Biomech 22:120-30 |
| Koh, Byung-Il; George, Alan D; Haftka, Raphael T et al. (2006) Parallel asynchronous particle swarm optimization. Int J Numer Methods Eng 67:578-595 |
| Fregly, Benjamin J; Rahman, Haseeb A; Banks, Scott A (2005) Theoretical accuracy of model-based shape matching for measuring natural knee kinematics with single-plane fluoroscopy. J Biomech Eng 127:692-9 |
| Schutte, Jaco F; Koh, Byung-Il; Reinbolt, Jeffrey A et al. (2005) Evaluation of a particle swarm algorithm for biomechanical optimization. J Biomech Eng 127:465-74 |
| Reinbolt, Jeffrey A; Schutte, Jaco F; Fregly, Benjamin J et al. (2005) Determination of patient-specific multi-joint kinematic models through two-level optimization. J Biomech 38:621-6 |
| Schutte, J F; Reinbolt, J A; Fregly, B J et al. (2004) Parallel global optimization with the particle swarm algorithm. Int J Numer Methods Eng 61:2296-2315 |
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