This proposed research project examines the association of childhood and adolescent affective and anxiety disorders with two specific genetic disorders involving X chromosome abnormalities in females, the fragile X (fra X) and Turner syndromes. The developmental course of affective and anxiety disorder symptoms and their association with social skills development will be investigated in these populations. Reports of increased mood and anxiety disorders among adult women with fra X or Turner syndrome indicate the need to study the presence and clinical features of these disorders in female children with these syndromes. The investigation also provides a compelling opportunity to elucidate the association between genetic factors involving the X chromosome with affective and anxiety disorders in children and adolescents. The specific hypotheses are: 1) Girls with fra X and girls with Turner syndrome will show greater frequency and severity of depression and anxiety disorders than their non-affected, female siblings; 2) The frequency and severity of depression and anxiety disorders will be maintained over time and indicate chronic, intermittent recurrence; 3) There will be a positive correlation between social skills deficits and severity of symptoms of depression and/or anxiety. Furthermore, social skills deficits ratings at initial assessment will be associated with the persistence of depression and anxiety at a follow-up assessment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Small Research Grants (R03)
Project #
5R03MH052311-02
Application #
2251987
Study Section
Child Psychopathology and Treatment Review Committee (CPT)
Project Start
1994-09-30
Project End
1996-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
2
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
167202410
City
Baltimore
State
MD
Country
United States
Zip Code
21205
Mazzocco, M M; Kates, W R; Baumgardner, T L et al. (1997) Autistic behaviors among girls with fragile X syndrome. J Autism Dev Disord 27:415-35
Gerring, J P; Freund, L; Gerson, A C et al. (1996) Psychometric characteristics of the Children's Motivation Scale. Psychiatry Res 63:205-17