This proposal is designed to test specific hypotheses regarding the functional role of different regions of prefrontal cortex (PFC) in both working memory (WM) and long-term memory (LTM) tasks. A growing literature has suggested the involvement of PFC in both WM and LTM. However, the findings within each memory domain have largely been considered independently of the other, such that functional interpretations of PFC activity are typically domain-specific. We propose two hypotheses that suggest more parsimonious explanations, interpreting PFC function in terms that apply across memory domains. First, we suggest that dorsolateral PFC (DL-PFC) is involved in the representation and maintenance of task-relevant context. We further suggest that task manipulations that vary the demand on context representation and maintenance will modulate DL-PFC activity, regardless of whether the task putatively involves WM or LTM. Second, we suggest that frontopolar PFC (FP-PFC) is involved in the representation and maintenance of higher-order goal information that can support and monitor the processing of lower-order sub-goals. We further suggest that task manipulations that vary the demand on sub-goal processing and monitoring will modulate activity in FP-PFC regardless of whether the task putatively involves WM or LTM. The studies proposed here will test these hypotheses by using state-of-the-art functional magnetic resonance imaging (fMRI) techniques, including novel event-related methods. Specifically, we will assess whether DL-PFC and FP-PFC activity can be modulated in either WM or LTM by selectively manipulating common task factors. Success in this work would represent a significant advance in both our theoretical and empirical efforts. With regard to theoretical efforts, demonstrating that distinct PFC regions play specific and common functional roles across memory domains would provide an important integration of the literatures on PFC function, WM, and LTM. With regard to empirical efforts, this work would lay the groundwork for the development of powerful new behavioral, as well as neuroimaging probes of cognitive and neurobiological function in both healthy populations and in clinical populations suffering from memory impairments.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Small Research Grants (R03)
Project #
1R03MH061615-01
Application #
6089975
Study Section
Special Emphasis Panel (ZRG1-IFCN-7 (01))
Program Officer
Anderson, Kathleen C
Project Start
2000-04-28
Project End
2002-03-31
Budget Start
2000-04-28
Budget End
2001-03-31
Support Year
1
Fiscal Year
2000
Total Cost
$74,419
Indirect Cost
Name
Washington University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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Speer, Nicole K; Jacoby, Larry L; Braver, Todd S (2003) Strategy-dependent changes in memory: effects on behavior and brain activity. Cogn Affect Behav Neurosci 3:155-67
Braver, Todd S; Bongiolatti, Susan R (2002) The role of frontopolar cortex in subgoal processing during working memory. Neuroimage 15:523-36