The basal ganglia are thought to play a critical role in adaptive behavior and cognition in general, and movement preparation, initiation, control and sequencing in particular. However, the relative contributions and roles of the various sub-components of the basal ganglia are not known. The overarching goal of this proposal is to characterize the differential contributions of dorsal basal ganglia (dBG) nuclei during the sequential organization of behavior. The proposed study aims to extend and amplify our previous findings of reliable and differential fMRI activation of the anterior caudate, anterior and posterior putamen and globus pallidus during movement sequencing. We plan to investigate in greater detail dBG involvement in various specific components of movement sequencing, and to examine the relationship between dBG activation, overall behavior, and specific behavioral performance measures such as reaction time and accuracy. Although the primary focus of this study is the dBG, the relative signal change, spatial extent and time course of activation in neocortical motor areas and the cerebellum will be also be examined. In addition, functional relations between the posterior putamen and globus pallidus, thalamus, cerebellum and cortical motor areas receiving dBG output will also be examined. Study 1 will investigate dBG function during movement sequencing in relation to specific and measurable changes in behavior. We will examine the effect of rate of movement on dBG activation during sequencing of unpredictable and predictable movements. Study 2 will investigate dBG function in relation to specific components involved in motor control during movement sequencing using event-related fMRI. Together these studies will more convincingly relate dBG to behavior during movement sequencing. More broadly, contrasting the roles of the dBG, motor cortex, SMA, pre-SMA and the cerebellum will yield significant information about distributed brain processes involved in the sequential organization of behavior. Results from the proposed studies will provide additional insights regarding the role of the dBG in adaptive behavior. Furthermore, the proposed research will aid in understanding and treating basal ganglia disorders, such as schizophrenia, ADHD, Huntington's disease, Parkinson's disease, and Tourette's syndrome.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Small Research Grants (R03)
Project #
1R03MH062430-01A1
Application #
6384180
Study Section
Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
Program Officer
Anderson, Kathleen C
Project Start
2001-09-15
Project End
2003-08-31
Budget Start
2001-09-15
Budget End
2002-08-31
Support Year
1
Fiscal Year
2001
Total Cost
$75,650
Indirect Cost
Name
Stanford University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Tamm, Leanne; Barnea-Goraly, Naama; Reiss, Allan L (2012) Diffusion tensor imaging reveals white matter abnormalities in Attention-Deficit/Hyperactivity Disorder. Psychiatry Res 202:150-4
Eckert, Mark A; Kamdar, Nirav V; Chang, Catherine E et al. (2008) A cross-modal system linking primary auditory and visual cortices: evidence from intrinsic fMRI connectivity analysis. Hum Brain Mapp 29:848-57
Chang, Catherine; Crottaz-Herbette, Sonia; Menon, Vinod (2007) Temporal dynamics of basal ganglia response and connectivity during verbal working memory. Neuroimage 34:1253-69
Tamm, Leanne; Menon, Vinod; Reiss, Allan L (2006) Parietal attentional system aberrations during target detection in adolescents with attention deficit hyperactivity disorder: event-related fMRI evidence. Am J Psychiatry 163:1033-43
Crottaz-Herbette, S; Lau, K M; Glover, G H et al. (2005) Hippocampal involvement in detection of deviant auditory and visual stimuli. Hippocampus 15:132-9
Greicius, Michael D; Srivastava, Gaurav; Reiss, Allan L et al. (2004) Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI. Proc Natl Acad Sci U S A 101:4637-42
Greicius, Michael D; Boyett-Anderson, Jesse M; Menon, Vinod et al. (2004) Reduced basal forebrain and hippocampal activation during memory encoding in girls with fragile X syndrome. Neuroreport 15:1579-83
Crottaz-Herbette, S; Anagnoson, R T; Menon, V (2004) Modality effects in verbal working memory: differential prefrontal and parietal responses to auditory and visual stimuli. Neuroimage 21:340-51
Levitin, Daniel J; Menon, Vinod (2003) Musical structure is processed in ""language"" areas of the brain: a possible role for Brodmann Area 47 in temporal coherence. Neuroimage 20:2142-52
Greicius, Michael D; Krasnow, Ben; Reiss, Allan L et al. (2003) Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci U S A 100:253-8

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