This research is intended to capitalize on the wealth of data already collected on a large group of patients with schizophrenia and healthy volunteers. These subjects were scanned twice over a 4-7 year period with high-resolution MRI for anatomical brain images and with duffusion-tensor imaging sequence for the visualization of white matter tracts. The resulting set of data is unique in that it provides detailed information not only on brain structure, but also on the white matter connections between various regions of the brain and their changes over an approximately 5-year period. To the best of our knowledge, no longitudinal studies of white matter tracts in patients with schizophrenia have ever yet been published. Moreover, patients with schizophrenia in the proposal were divided into those with good outcomes to their illness (i.e. capable of independent living) and those with very poor outcomes, who are unable to care for themselves or obtain basic necessities of life such as food, clothing, and shelter. Patients with this type of poor-outcome illness constitute the vast majority of chronically institutionalized inpatients in the state psychiatric hospitals. We plan to analyze this dataset in detail, specifically evaluating the course and progression of gray and white matter deficits over the 5-year period in schizophrenia patients with good and poor outcomes. Understanding the differences in disease progression in these two groups of patients is the key for better delineation of the poor-outcome subtype of schizophrenia. It may potentially lead to early diagnosis of this very severe subtype of the illness and to the development of early pharmacological interventions aimed at prevention of disease progression, hence - chronic institutionalization of these patients. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Small Research Grants (R03)
Project #
1R03MH077146-01A1
Application #
7199593
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Meinecke, Douglas L
Project Start
2006-12-05
Project End
2008-11-30
Budget Start
2006-12-05
Budget End
2007-11-30
Support Year
1
Fiscal Year
2007
Total Cost
$83,360
Indirect Cost
Name
Mount Sinai School of Medicine
Department
Psychiatry
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Mitelman, Serge A; Bralet, Marie-Cecile; Mehmet Haznedar, M et al. (2018) Positron emission tomography assessment of cerebral glucose metabolic rates in autism spectrum disorder and schizophrenia. Brain Imaging Behav 12:532-546
Mitelman, Serge A; Canfield, Emily L; Brickman, Adam M et al. (2010) Progressive ventricular expansion in chronic poor-outcome schizophrenia. Cogn Behav Neurol 23:85-8
Mitelman, Serge A; Canfield, Emily L; Chu, King-Wai et al. (2009) Poor outcome in chronic schizophrenia is associated with progressive loss of volume of the putamen. Schizophr Res 113:241-5
Mitelman, Serge A; Nikiforova, Yekaterina K; Canfield, Emily L et al. (2009) A longitudinal study of the corpus callosum in chronic schizophrenia. Schizophr Res 114:144-53
Mitelman, Serge A; Torosjan, Yuliya; Newmark, Randall E et al. (2007) Internal capsule, corpus callosum and long associative fibers in good and poor outcome schizophrenia: a diffusion tensor imaging survey. Schizophr Res 92:211-24
Mitelman, Serge A; Buchsbaum, Monte S (2007) Very poor outcome schizophrenia: clinical and neuroimaging aspects. Int Rev Psychiatry 19:345-57
Mitelman, Serge A; Brickman, Adam M; Shihabuddin, Lina et al. (2007) A comprehensive assessment of gray and white matter volumes and their relationship to outcome and severity in schizophrenia. Neuroimage 37:449-62