Funding Agency

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Small Research Grants (R03)
Project #
2R03TW000171-04
Application #
2291649
Study Section
International and Cooperative Projects 1 Study Section (ICP)
Project Start
1993-04-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Psychiatry
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Jakubik, J; El-Fakahany, E E; Tucek, S (2000) Evidence for a tandem two-site model of ligand binding to muscarinic acetylcholine receptors. J Biol Chem 275:18836-44
Dolezal, V; Tucek, S (1999) Calcium channels involved in the inhibition of acetylcholine release by presynaptic muscarinic receptors in rat striatum. Br J Pharmacol 127:1627-32
Lysikova, M; Fuksova, K; Elbert, T et al. (1999) Subtype-selective inhibition of [methyl-3H]-N-methylscopolamine binding to muscarinic receptors by alpha-truxillic acid esters. Br J Pharmacol 127:1240-6
Dolezal, V; Tucek, S (1998) The effects of brucine and alcuronium on the inhibition of [3H]acetylcholine release from rat striatum by muscarinic receptor agonists. Br J Pharmacol 124:1213-8
Jakubik, J; Haga, T; Tucek, S (1998) Effects of an agonist, allosteric modulator, and antagonist on guanosine-gamma-[35S]thiotriphosphate binding to liposomes with varying muscarinic receptor/Go protein stoichiometry. Mol Pharmacol 54:899-906
Jakubik, J; Bacakova, L; El-Fakahany, E E et al. (1997) Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol 52:172-9
Jakubik, J; Tucek, S (1995) Positive allosteric interactions on cardiac muscarinic receptors: effects of chemical modifications of disulphide and carboxyl groups. Eur J Pharmacol 289:311-9
Jakubik, J; Bacakova, L; el-Fakahany, E E et al. (1995) Constitutive activity of the M1-M4 subtypes of muscarinic receptors in transfected CHO cells and of muscarinic receptors in the heart cells revealed by negative antagonists. FEBS Lett 377:275-9
Jakubik, J; Bacakova, L; el-Fakahany, E E et al. (1995) Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors. J Pharmacol Exp Ther 274:1077-83
Proska, J; Tucek, S (1995) Competition between positive and negative allosteric effectors on muscarinic receptors. Mol Pharmacol 48:696-702

Showing the most recent 10 out of 11 publications