The specific aims include: (1) Determination of the biological phenotype (tropism, replication and syncytium-forming ability of the isolates) of HIV-1 isolates obtained around seroconversion in individuals who acquire HIV infection through heterosexual contact. (2) Genotypic characterization of the isolates. Specifically sequence variation in the envelope gene within and between individuals will be carried out and (3) Determination of the infectivity and replicative ability in langerhans cells of HIV-1 isolates obtained early after infection from subjects infected heterosexually.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Small Research Grants (R03)
Project #
1R03TW000555-01
Application #
2292226
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1995-09-30
Project End
1998-09-29
Budget Start
1995-09-30
Budget End
1996-09-29
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Harvard University
Department
Biology
Type
Schools of Public Health
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115