Abstract

The purpose of this study is to evaluate the interactions of angiotensin II (Ang II) and arachidonic acid (AA) metabolites in the regulation of ion transport in the medullary thick ascending limb (mTAL) in the rat kidney. This study will investigate Ang II-induced changes in ion transport in the mTAL by correlating them with Ang II-induced release of eicosanoids. This study will also investigate the possible role of tumor necrosis factor (TNF) in response to Ang II.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Small Research Grants (R03)
Project #
5R03TW000706-02
Application #
2685843
Study Section
International and Cooperative Projects 1 Study Section (ICP)
Project Start
1997-04-01
Project End
2000-03-31
Budget Start
1998-04-01
Budget End
1999-03-31
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
New York Medical College
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Valhalla
State
NY
Country
United States
Zip Code
10595

  Publications

Carroll, Mairead A; Ferreri, Nicholas R; Escalante, Bruno A et al. (2003) Cytochrome P450 arachidonic acid metabolites modulate renal tubular function. Adv Exp Med Biol 525:67-9
Escalante, Bruno A; McGiff, John C; Oyekan, Adebayo O (2002) Role of cytochrome P-450 arachidonate metabolites in endothelin signaling in rat proximal tubule. Am J Physiol Renal Physiol 282:F144-50
Naftolin, F; Bruhlmann-Papazyan, M; Baetens, D et al. (1985) Neurons with whorl bodies have increased numbers of synapses. Brain Res 329:289-93