One of the risk factors for essential hypertension is salt-sensitivity ; however, the metabolic, cellular, and molecular mechanisms involved in increased pressor response to Na-loading are not known. Metabolic and genetic studies of the causes of salt-sensitivity should be especially fruitful in normotensive and hypertensive African-Americans because they have a higher prevalence of salt-sensitivity . Altered Na homeostasis is marked by increased intracellular Na (Na-i) levels, depressed Rb+ uptake and depressed Na pump activity and these may be important phenotypic markers for salt-sensitive hypertension. Because eicosanoid products of cytochrome P450-dependent arachidonic acid metabolism inhibit Na pump activity, these products may also be important markers of hypertension. In addition, based on reports in the literature, polymorphisms of the alpha-1 Na,K-ATPase (Na pump) and the Type 1 amiloride sensitive Na channel loci may affect hypertension. The current proposal will extend ongoing studies in African-Americans in Cleveland to a Ugandan population. Prevalence of hypertension will be estimated, as well as the relationship between hypertension, environmental risk factors, intermediate phenotypes (for example, Na-i and cytochrome P450-dependent arachidonic acid metabolites), and genotypes at the two candidate loci.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Small Research Grants (R03)
Project #
5R03TW000760-03
Application #
2901500
Study Section
International and Cooperative Projects 1 Study Section (ICP)
Program Officer
Michels, Kathleen M
Project Start
1997-04-01
Project End
2000-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106