This proposal is a revision of a previously submitted Fogarty International Collaboration Research Award (FIRCA 1 R03 TW05888-01). The proposed study takes advantage of the economy of the screening and follow-up of older adults participating in a project sponsored by the Mexican Institute of Social Security and the Mexican Institute of Psychiatry and will enhance the ability to study depression and cognition among older primary care patients. Our proposed study will add genotyping for APOE, a susceptibility gene for Alzheimer's disease, to the assessments of 3,000 older Mexicans who will be followed for 5 years, to address how APOE genotype and cognitive functioning assessed at baseline are related to the form and course of depressive symptoms and cognitive impairment in older primary care patients. We will compare our findings with a similar survey being carried out in the United States (The """"""""Spectrum survey""""""""; the parent study NIMH MH62210-01).
The specific aims of this study to be carried out in primary care settings in Mexico are: 1 to evaluate the extent to which the epsilon4 allele of the Apolipoprotein E gene modifies the association of depressive symptoms with executive and cognitive impairment over the follow-up period; and, 2 to assess whether the effect modification of the association between depressive symptoms and executive and cognitive functioning by the e4 allele of the Apolipoprotein E gene is consistent across ethnic groups (African-Americans, whites living in the United States, and Mexicans). Our Mexican collaborators have contributed to the preparation of this FIRCA and we have met in Philadelphia and Mexico City to consider the response to the reviewers' comments. The proposed work will contribute to the knowledge of the role of APOE in cognition and depression among older Mexicans and will provide the impetus for the development of new research capacity in Mexico that will enhance the ability to do population-based research on genetics.
| García-Peña, Carmen; Wagner, Fernando A; Sánchez-García, Sergio et al. (2013) Late-life depressive symptoms: prediction models of change. J Affect Disord 150:886-94 |
| Pérez-Zepeda, Mario Ulises; Arango-Lopera, Victoria Eugenia; Wagner, Fernando A et al. (2013) Factors associated with help-seeking behaviors in Mexican older individuals with depressive symptoms: a cross-sectional study. Int J Geriatr Psychiatry 28:1260-9 |
| Juarez-Cedillo, T; Sanchez-Garcia, S; Mould-Quevedo, J F et al. (2010) Cost-effective analysis of genotyping using oral cells in the geriatric population. Genet Mol Res 9:1886-95 |
| Franco-Marina, Francisco; García-González, Jose Juan; Wagner-Echeagaray, Fernando et al. (2010) The Mini-mental State Examination revisited: ceiling and floor effects after score adjustment for educational level in an aging Mexican population. Int Psychogeriatr 22:72-81 |
| Garcia-Pena, Carmen; Juarez-Cedillo, Teresa; Cruz-Robles, David et al. (2010) Depressive symptoms and APOE polymorphisms in an elderly population-based sample. Psychiatr Genet 20:215-20 |
| Garcia-Pena, Carmen; Wagner, Fernando A; Sanchez-Garcia, Sergio et al. (2008) Depressive symptoms among older adults in Mexico City. J Gen Intern Med 23:1973-80 |
| Sanchez-Garcia, Sergio; Juarez-Cedillo, Teresa; Garcia-Gonzalez, Jose Juan et al. (2008) Usefulness of two instruments in assessing depression among elderly Mexicans in population studies and for primary care. Salud Publica Mex 50:447-56 |
