? This application is for support of collaborative research conducted by Dr. Timothy Ryan (U.S. Principal Investigator) and Dr. Felipe Barros (Foreign Collaborator; Chile). The U.S. P.I. has a long standing interest on the regulation of vesicle traffic in synaptic terminals, and how this traffic impacts synaptic function. The current proposal extends the breadth of his investigations by considering how synaptic activity is matched by glucose transport and how the metabolic load is shared between neurons and their surrounding astrocytes. The Foreign Collaborator, Dr. Felipe Barros, has experience on the mechanisms of glucose transport activation by metabolic stress and has recently developed methods based on confocal microscopy for realtime measurement of hexose transport in single astrocytes and neurons. The proposal, based on fluorescence imaging, will combine the know how of the US laboratory on synaptic transmission with the expertise of the Chilean laboratory on glucose transport. It is expected that this research will shed new light on the molecular mechanisms that underlie functional imaging of the brain in vivo. ? ?

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Small Research Grants (R03)
Project #
1R03TW007024-01A1
Application #
6988744
Study Section
International and Cooperative Projects 1 Study Section (ICP)
Program Officer
Michels, Kathleen M
Project Start
2005-07-01
Project End
2007-06-30
Budget Start
2005-07-01
Budget End
2006-06-30
Support Year
1
Fiscal Year
2005
Total Cost
$40,320
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Porras, Omar H; Ruminot, Ivan; Loaiza, Anitsi et al. (2008) Na(+)-Ca(2+) cosignaling in the stimulation of the glucose transporter GLUT1 in cultured astrocytes. Glia 56:59-68
Barros, L F; Bittner, Carla X; Loaiza, Anitsi et al. (2007) A quantitative overview of glucose dynamics in the gliovascular unit. Glia 55:1222-37