The overall aim of this study is to provide a comprehensive picture of the course and outcome of four specific personality disorders (PDs): schizotypal (STPD), borderline (BPD) avoidant (AVPD) and obsessive- compulsive (OCPD). Using a prospective longitudinal, repeated measures design we will develop the same basic knowledge about course and outcome for the PDs that has previously resulted from similar investigations of affective and anxiety disorders. The absence of comparable data for individuals diagnosed with PDs represents an important gap in knowledge. To accomplish our overall aim we propose three approaches: I. descriptive, II. predictive, and III. validating. The descriptive approach will provide the basic data on stability of psychopathology and social impairment that allows comparison between the PDs and to similar data from Axis I disorders. The predictive approach will yield basic clinical insights into the determinants of prognosis within and across PDs. The validating approach will examine the homogeneity of descriptive and longitudinal features for the PDs as defined by the DSM system and how this compares with alternative schemes. To accomplish these aims, this proposal requests funds to recruit rigorously assess, and follow a total sample of 750 subjects, aged 18 to 45, i.e., 150 of each of the four PDs and 150 controls with major depressive disorder (MDD) . The sample will be large enough and sufficiently diverse ethnically to attain results generalizable to most clinical settings and to examine the application of several dimensional approaches.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Unknown (R10)
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Special Emphasis Panel (ZMH1-CRB-J (O2))
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Mc Lean Hospital (Belmont, MA)
United States
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Wright, Aidan G C; Hopwood, Christopher J; Skodol, Andrew E et al. (2016) Longitudinal validation of general and specific structural features of personality pathology. J Abnorm Psychol 125:1120-1134
Ruocco, Anthony C; Hudson, James I; Zanarini, Mary C et al. (2015) Familial aggregation of candidate phenotypes for borderline personality disorder. Personal Disord 6:75-80
Ansell, Emily B; Wright, Aidan G C; Markowitz, John C et al. (2015) Personality disorder risk factors for suicide attempts over 10 years of follow-up. Personal Disord 6:161-7
Gunderson, John G; Stout, Robert L; Shea, M Tracie et al. (2014) Interactions of borderline personality disorder and mood disorders over 10 years. J Clin Psychiatry 75:829-34
Thomas, Katherine M; Hopwood, Christopher J; Donnellan, M Brent et al. (2014) Personality heterogeneity in PTSD: distinct temperament and interpersonal typologies. Psychol Assess 26:23-34
Hopwood, Christopher J; Morey, Leslie C; Donnellan, M Brent et al. (2013) Ten-year rank-order stability of personality traits and disorders in a clinical sample. J Pers 81:335-44
Grilo, Carlos M; Pagano, Maria E; Stout, Robert L et al. (2012) Stressful life events predict eating disorder relapse following remission: six-year prospective outcomes. Int J Eat Disord 45:185-92
Morey, L C; Hopwood, C J; Markowitz, J C et al. (2012) Comparison of alternative models for personality disorders, II: 6-, 8- and 10-year follow-up. Psychol Med 42:1705-13
Cain, Nicole M; Ansell, Emily B; Wright, Aidan G C et al. (2012) Interpersonal pathoplasticity in the course of major depression. J Consult Clin Psychol 80:78-86
Yen, Shirley; Shea, M Tracie; Walsh, Zach et al. (2011) Self-harm subscale of the Schedule for Nonadaptive and Adaptive Personality (SNAP): predicting suicide attempts over 8 years of follow-up. J Clin Psychiatry 72:1522-8

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