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Gupton, John T; Shimozono, Alex; Crawford, Evan et al. (2018) Further studies on the application of vinylogous amides and ?-halovinylaldehydes to the regiospecific synthesis of unsymmetrical, polyfunctionalized 2,3,4- and 1,2,3,4- substituted pyrroles. Tetrahedron 74:2650-2663
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Gilmore, Samuel P; Gonye, Anna L K; Li, Elizabeth C et al. (2018) Effects of a novel microtubule-depolymerizer on pro-inflammatory signaling in RAW264.7 macrophages. Chem Biol Interact 280:109-116
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Gupton, John T; Yeudall, Scott; Telang, Nakul et al. (2017) Ortho group activation of a bromopyrrole ester in Suzuki-Miyaura cross-coupling reactions: Application to the synthesis of new microtubule depolymerizing agents with potent cytotoxic activities. Bioorg Med Chem 25:3206-3214
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Rohena, Cristina C; Telang, Nakul S; Da, Chenxiao et al. (2016) Biological Characterization of an Improved Pyrrole-Based Colchicine Site Agent Identified through Structure-Based Design. Mol Pharmacol 89:287-96
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Ciemniecki, John A; Lewis, Clarke P; Gupton, John T et al. (2016) Effects of a pyrrole-based, microtubule-depolymerizing compound on RAW 264.7 macrophages. Chem Biol Interact 246:63-8
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Gupton, John T; Telang, Nakul; Wormald, Michael et al. (2014) Formyl Group Activation of a Bromopyrrole Ester in Suzuki Cross-Coupling Reactions: Application to a Formal Synthesis of Polycitone A and B and Polycitrin A. Tetrahedron 70:2738-2745
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Gupton, John T; Telang, Nakul; Patteson, Jon et al. (2014) The application of formyl group activation of bromopyrrole esters to formal syntheses of lycogarubin C, permethyl storniamide A and lamellarin G trimethyl ether. Tetrahedron 70:9759-9767
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Da, Chenxiao; Mooberry, Susan L; Gupton, John T et al. (2013) How to deal with low-resolution target structures: using SAR, ensemble docking, hydropathic analysis, and 3D-QSAR to definitively map the **-tubulin colchicine site. J Med Chem 56:7382-95
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Biggers, Jonathan W; Nguyen, Tuyen; Di, Xu et al. (2013) Autophagy, cell death and sustained senescence arrest in B16/F10 melanoma cells and HCT-116 colon carcinoma cells in response to the novel microtubule poison, JG-03-14. Cancer Chemother Pharmacol 71:441-55
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Gupton, John T; Telang, Nakul; Gazzo, Dominic F et al. (2013) Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles. Tetrahedron 69:5829-5840
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Showing the most recent 10 out of 19 publications
