Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Academic Research Enhancement Awards (AREA) (R15)
Project #
1R15CA078232-01A1
Application #
2806072
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Program Officer
Forry, Suzanne L
Project Start
1999-04-05
Project End
2003-03-31
Budget Start
1999-04-05
Budget End
2003-03-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Montana
Department
Other Health Professions
Type
Schools of Pharmacy
DUNS #
City
Missoula
State
MT
Country
United States
Zip Code
59812
Cai, Wen; Hassani, Mary; Karki, Rajesh et al. (2010) Synthesis, metabolism and in vitro cytotoxicity studies on novel lavendamycin antitumor agents. Bioorg Med Chem 18:1899-909
Hassani, Mary; Cai, Wen; Koelsch, Katherine H et al. (2008) Lavendamycin antitumor agents: structure-based design, synthesis, and NAD(P)H:quinone oxidoreductase 1 (NQO1) model validation with molecular docking and biological studies. J Med Chem 51:3104-15
Fryatt, Tara; Pettersson, Hanna I; Gardipee, Walter T et al. (2004) Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1). Bioorg Med Chem 12:1667-87
Bunderson, Melisa; Coffin, J Douglas; Beall, Howard D (2002) Arsenic induces peroxynitrite generation and cyclooxygenase-2 protein expression in aortic endothelial cells: possible role in atherosclerosis. Toxicol Appl Pharmacol 184:11-8
Whatmore, Jacqueline L; Swann, Elizabeth; Barraja, Paola et al. (2002) Comparative study of isoflavone, quinoxaline and oxindole families of anti-angiogenic agents. Angiogenesis 5:45-51
Swann, E; Barraja, P; Oberlander, A M et al. (2001) Indolequinone antitumor agents: correlation between quinone structure and rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase. Part 2. J Med Chem 44:3311-9
Beall, H D; Winski, S I (2000) Mechanisms of action of quinone-containing alkylating agents. I: NQO1-directed drug development. Front Biosci 5:D639-48
Fryatt, T; Goroski, D T; Nilson, Z D et al. (1999) Novel quinolinequinone antitumor agents: structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1). Bioorg Med Chem Lett 9:2195-8