Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Academic Research Enhancement Awards (AREA) (R15)
Project #
3R15DA016604-01S1
Application #
6937473
Study Section
Molecular, Cellular and Developmental Neurosciences 2 (MDCN)
Program Officer
Rapaka, Rao
Project Start
2003-08-01
Project End
2006-07-31
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
1
Fiscal Year
2004
Total Cost
$37,604
Indirect Cost

  Institution

Name
Duquesne University
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
004501193
City
Pittsburgh
State
PA
Country
United States
Zip Code
15282

  Publications

Lapinsky, David J; Aggarwal, Shaili; Nolan, Tammy L et al. (2012) (±)-2-(N-tert-Butylamino)-3'-[(125)I]-iodo-4'-azidopropiophenone: a dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin, Zyban). Bioorg Med Chem Lett 22:523-6
Lapinsky, David J; Yarravarapu, Nageswari; Nolan, Tammy L et al. (2012) Evolution of a Compact Photoprobe for the Dopamine Transporter Based on (±)-threo-Methylphenidate. ACS Med Chem Lett 3:378-382
Lapinsky, David J; Velagaleti, Ranganadh; Yarravarapu, Nageswari et al. (2011) Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling. Bioorg Med Chem 19:504-12
Indarte, Martín; Liu, Yi; Madura, Jeffry D et al. (2010) Receptor-Based Discovery of a Plasmalemmal Monoamine Transporter Inhibitor via High Throughput Docking and Pharmacophore Modeling. ACS Chem Neurosci 1:223-233
Lapinsky, David J; Aggarwal, Shaili; Huang, Yurong et al. (2009) A novel photoaffinity ligand for the dopamine transporter based on pyrovalerone. Bioorg Med Chem 17:3770-4
Indarte, Martin; Madura, Jeffry D; Surratt, Christopher K (2008) Dopamine transporter comparative molecular modeling and binding site prediction using the LeuT(Aa) leucine transporter as a template. Proteins 70:1033-46
Ukairo, Okechukwu T; Ramanujapuram, Suneetha; Surratt, Christopher K (2007) Fluctuation of the dopamine uptake inhibition potency of cocaine, but not amphetamine, at mammalian cells expressing the dopamine transporter. Brain Res 1131:68-76
Ukairo, Okechukwu T; Bondi, Corry D; Newman, Amy Hauck et al. (2005) Recognition of benztropine by the dopamine transporter (DAT) differs from that of the classical dopamine uptake inhibitors cocaine, methylphenidate, and mazindol as a function of a DAT transmembrane 1 aspartic acid residue. J Pharmacol Exp Ther 314:575-83
Surratt, Christopher K; Ukairo, Okechukwu T; Ramanujapuram, Suneetha (2005) Recognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transporters. AAPS J 7:E739-51