Drugs of abuse are associated with a variety of cognitive deficits including disruption of learning and memory. Animal models are needed to better assess the cognitive risks of use and abuse of psychoactive drugs and the studies completed during the current grant period developed promising procedures to assess drug effects on memory capacity in rats. The proposed work will focus on five key drugs (CDZ, scopolamine, MDMA, DZP and ketamine) of particular interest based on the effects observed in our preliminary work. These proposed studies will 1) use a more refined measure of memory load to test the hypothesis that drug effects in our recently completed studies might have been influenced by attentional factors due the use of multiple distractors. 2) Use a list memory procedure that permits the analysis of both the number of stimuli to remember and the retention interval to test the hypothesis that these drugs have different actions on recognition memory: i.e., NMDA antagonist effects depend on memory load, whereas MDMA, CDZ, and scopolamine effects are delay-dependent. 3) Use an odor list task that includes test trials separating responding based on relative familiarity versus recollection of specific episode sequences to test the hypothesis that NMDA antagonists impair both familiarity and episodic-like memory processes, whereas CDZ, and scopolamine spare familiarity, and MDMA spares both processes. Finally, the proposed research will provide an ideal opportunity for students to develop skills and background in psychopharmacology and neuroscience.

Public Health Relevance

Drugs of abuse may produce cognitive deficits and this project will determine the effects of five key drugs on recognition memory in rats using tasks designed to assess memory capacity. Improved assessment of the effects of drugs of abuse on memory has considerable potential public health significance.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Academic Research Enhancement Awards (AREA) (R15)
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Biobehavioral Regulation, Learning and Ethology Study Section (BRLE)
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Lynch, Minda
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University of North Carolina Wilmington
Schools of Arts and Sciences
United States
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Bruce, Katherine; Dyer, Katherine; Mathews, Michael et al. (2018) Successive odor matching- and non-matching-to-sample in rats: A reversal design. Behav Processes 155:26-32
Mathews, Michael J; Mead, Ralph N; Galizio, Mark (2018) Effects of N-Methyl-D-aspartate (NMDA) antagonists ketamine, methoxetamine, and phencyclidine on the odor span test of working memory in rats. Exp Clin Psychopharmacol 26:6-17
Galizio, Mark; Mathews, Michael; Mason, Madeleine et al. (2017) Amnestic drugs in the odor span task: Effects of flunitrazepam, zolpidem and scopolamine. Neurobiol Learn Mem 145:67-74
Galizio, Mark (2016) Olfactory Stimulus Control and the Behavioral Pharmacology of Remembering. Behav Anal (Wash D C) 16:169-178
Galizio, Mark; April, Brooke; Deal, Melissa et al. (2016) Behavioral pharmacology of the odor span task: Effects of flunitrazepam, ketamine, methamphetamine and methylphenidate. J Exp Anal Behav 106:173-194
Prichard, Ashley; Panoz-Brown, Danielle; Bruce, Katherine et al. (2015) Emergent identity but not symmetry following successive olfactory discrimination training in rats. J Exp Anal Behav 104:133-45
Galizio, Mark; Byrd, Bridget D; Robinson, Andrea M et al. (2014) Repeated Acquisition in the Morris Swim Task: Effects of MDMA, Methamphetamine and Methylphenidate. Psychol Rec 64:143-150
Branch, Carrie L; Galizio, Mark; Bruce, Katherine (2014) What-Where-When Memory in the Rodent Odor Span Task. Learn Motiv 47:18-29
Hawkey, Andrew; April, L Brooke; Galizio, Mark (2014) Effects of MDMA on olfactory memory and reversal learning in rats. Neurobiol Learn Mem 114:209-16
April, L Brooke; Bruce, Katherine; Galizio, Mark (2013) The Magic Number 70 (plus or minus 20): Variables Determining Performance in the Rodent Odor Span Task. Learn Motiv 44:143-158

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