Form Approved Through 09/30/2007 Department of Health and Human Services 2 R15 GM069323-02 IPF:1618801 Iff) 0 1 2 0 I P7'ea'th ^iCe;. Dua,:A, AlDS/EXPED V Grant Application IRG: ADDT Recejved:12/23/20Q4 Do not exceed character lengthrestrictions indicated. 1. TITLE OF PROJECT (Do not exceed 81 characters, including spaces and punctuation.) Hydrophobicity in HIV-1 Protease lnhibition:QSAR Study 2. RESPONSETOSPECIFIC REQUEST FOR APPLICATIONS ORPROGRAMANNOUNCEMENT ORSOLICITATION Q NO^ YES (If 'Yes, 'state number andtitle) Number: PA-03-053 Title: Academic Research Enhancement Award 3. PRINCIPAL INVESTIGATOR/PROGRAMDIRECTOR New Investigator Q No [X] Yes 3a. NAME (Last, first, middle) 3b. DEGREE(S) 3h. eRA Commons User Name Garg, Rajni Ph.D. RGARG01 3c. POSITION TITLE 3d. MAILING ADDRESS (Street, city, state, zip code) Research Associate Professor 8 Clarkson Avenue 3e. DEPARTMENT, SERVICE, LABORATORY, OR EQUIVALENT 247 Science Center, Box 5810 Department of Chemistry Potsdam, NY 13699-5810 3f. MAJOR SUBDIVISION School of Science 3g. TELEPHONE AND FAX (Area code, number and extension) E-MAIL ADDRESS: TEL: 315-268-4421 FAX: 315-268-6610 rgarg@clarkson.edu 4. HUMAN SUBJECTS 4b Human Sut)JectsAssurance No. 5. VERTEBRATE ANIMALS ^ No Q Yes PFRFARHH ,_. .| Ac.Clinical Trial 4d. NIH-defined Phase III 5a. If 'Yes,' IACUC approval 5b. Animal welfare assurance no. Kl NoU Yes n No D Yes Clinical Trial D No D Yes Date 4a. Research Exempt ,, .. _ ,. .. ._, _ If Yes,Exemption No. D No D Yes 6. DATES OF PROPOSED PERIOD OF 7. COSTS REQUESTED FOR INITIAL 8. COSTS REQUESTED FOR PROPOSED SUPPORT (month, day, yearMM/DD/YY) BUDGET PERIOD PERIOD OF SUPPORT From Through 7a. Direct Costs ($) 7b. Total Costs ($) 8a. Direct Costs ($) 8b. Total Costs ($) 08/01/2005 07/31/2008 $50,000 $79,500 $150,000 $238,500 9. APPLICANT ORGANIZATION 10. TYPE OF ORGANI2ATION Name Clarkson University Public: -> I I Federal I I State I I Local Address Division of Research, Box 5630, 8 Clarkson Avenue, Private: -> E^l Private Nonprofit Potsdam, NY 13699-5630 For-profit: - l~l General ED Small Business [H Woman-owned f~1 Socially and EconomicallyDisadvantaged 11 . ENTITY IDENTIFICATION NUMBER 150543659 DUNS NO. 041590993 Cong. District 24th 12. ADMINISTRATIVE OFFICIAL TO BE NOTIFIED IF AWARD IS MADE 13. OFFICIAL SIGNING FOR APPLICANTORGANIZATION Name Dr. Goodarz Ahmadi Name Dr. Goodarz Ahmadi Title Interim Vice Provost for Research Title interim Vice Provost for Research Address ciarkson University Address ciarkson University 8 Clarkson Avenue, P.O. Box 5630 Division of Research, Box 5630, 8 Clarkson Potsdam, NY 13699-5630 Avenue, Potsdam, NY 13699-5630 Tel: (315)268-3765 FAX: (315)268-6515 Tel: (315)268-3765 FAX: (315)268-6515 E-Mail: research@clarkson.edu E-Mail: research@clarkson.edu 14. PRINCIPAL INVESTIGATOR/PROGRAM DIRECTOR ASSURANCE: I certify that the SIGNATURE OF PI/PD NAMED IN 3a. DATE statements herein are true, complete and accurate to the best of my knowledge. Iam (In ink. 'Per' signature not acceptable.) aware that any false, fictitious, or fraudulent statements or claims may subject me to corinmdinuactl, ocfivthil,eoprraodjemctinaisntdrattoivperopveindaeltihees.reIqaugirede tporoagcrcespst repsoprotsnsifibailigtyrafnotr itsheawsacriednetdificas Ufc^ 'I*1' a result of this application. 15. APPLICANT ORGANIZATION CERTIFICATION AND ACCEPTANCE: I certify that SIGNATURE OF OFFICIAL NAMED IN 1 3. DATE the statements herein are true, complete and accurate to the best of my knowledge, and (In ink. 'Per' signature not acceptable.) accept the obligation to comply with Public Health Services terms and conditions if a grant is awarded as a result of this application. I am aware that any false, fictitious, or fraudulent statements or claims may subject me to criminal, civil, or administrative penalties. GocAr-2, fQ krvW L ^ I ^^ PHS 398 (Rev.09/04) Face Page Form Page 1 ========================================Section End===========================================
| Reddy, A Srinivas; Kumar, Sunil; Garg, Rajni (2010) Hybrid-genetic algorithm based descriptor optimization and QSAR models for predicting the biological activity of Tipranavir analogs for HIV protease inhibition. J Mol Graph Model 28:852-62 |
| Garg, Rajni; Bhhatarai, Barun (2008) Possible allosteric interactions of monoindazole-substituted P2 cyclic urea analogues with wild-type and mutant HIV-1 protease. J Comput Aided Mol Des 22:737-45 |
| Garg, Rajni; Patel, Disha (2005) Hydrophobicity in the design of P2/P2' tetrahydropyrimidinone HIV protease inhibitors. Bioorg Med Chem Lett 15:3767-70 |
| Bhhatarai, Barun; Garg, Rajni (2005) From SAR to comparative QSAR: role of hydrophobicity in the design of 4-hydroxy-5,6-dihydropyran-2-ones HIV-1 protease inhibitors. Bioorg Med Chem 13:4078-84 |
| Garg, Rajni; Bhhatarai, Barun (2004) A mechanistic study of 3-aminoindazole cyclic urea HIV-1 protease inhibitors using comparative QSAR. Bioorg Med Chem 12:5819-31 |
