The broad objective of this proposal is to examine the influence of fish oil (omega-3 fatty acids) on neurovascular control in humans. Specifically, this project will examine the effect of fish oil on: 1) resting blood pressure and muscle sympathetic nerve activity (MSNA) in normotensive and hypertensive individuals, and 2) neurovascular responses to mental stress in normotensive and hypertensive individuals.
The specific aims of this project are: 1. To determine the effect of fish oil on blood pressure and MSNA at rest in humans. Resting blood pressure and MSNA will be measured before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will reduce blood pressure in hypertensive subjects, and that reductions in blood pressure will be associated with reductions in resting MSNA. 2. To determine the effect of fish oil on blood pressure and MSNA responses to mental stress. MSNA responses to mental stress will be measured directly from the peroneal nerve before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will inhibit blood pressure and MSNA responses to mental stress in hypertensive subjects. 3. To determine the effect of fish oil on forearm and calf vascular responses to mental stress. Forearm and calf blood flow responses to mental stress will be simultaneously recorded using venous occlusion plethysmography before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will enhance the forearm vasodilation response to mental stress, and that this response will be more dramatic in hypertensive subjects. 4. To determine the effect of fish oil on sympathetic and vascular recovery responses to mental stress. Post mental-stress blood pressure, MSNA and blood flow will be measured before and after an eight-week fish oil supplementation period. Both normotensive and hypertensive subjects will be studied. It is hypothesized that fish oil will reduce the amount of time required to return blood pressure, MSNA, and blood flow to baseline conditions after mental stress. Fish oil reduces the incidence of cardiovascular disease, but the mechanisms underlying this relationship remain unclear. This project will provide new knowledge regarding the effect of fish oil on neurovascular control in both normotensive and hypertensive humans. ? ? ?
| Harvey, Ronee E; Hart, Emma C; Charkoudian, Nisha et al. (2015) Oral Contraceptive Use, Muscle Sympathetic Nerve Activity, and Systemic Hemodynamics in Young Women. Hypertension 66:590-7 |
| Carter, Jason R; Fu, Qi; Minson, Christopher T et al. (2013) Ovarian cycle and sympathoexcitation in premenopausal women. Hypertension 61:395-9 |
| Carter, Jason R; Schwartz, Christopher E; Yang, Huan et al. (2013) Fish oil and neurovascular reactivity to mental stress in humans. Am J Physiol Regul Integr Comp Physiol 304:R523-30 |
| Carter, Jason R; Schwartz, Christopher E; Yang, Huan et al. (2012) Fish oil and neurovascular control in humans. Am J Physiol Heart Circ Physiol 303:H450-6 |
| Schwartz, Christopher E; Durocher, John J; Carter, Jason R (2011) Neurovascular responses to mental stress in prehypertensive humans. J Appl Physiol 110:76-82 |
| Durocher, John J; Klein, Jenna C; Carter, Jason R (2011) Attenuation of sympathetic baroreflex sensitivity during the onset of acute mental stress in humans. Am J Physiol Heart Circ Physiol 300:H1788-93 |
| Klein, Jenna C; Crandall, Craig G; Brothers, R Matthew et al. (2010) Combined heat and mental stress alters neurovascular control in humans. J Appl Physiol (1985) 109:1880-6 |
| Lawrence, Johnathan E; Klein, Jenna C; Carter, Jason R (2010) Menstrual cycle elicits divergent forearm vascular responses to vestibular activation in humans. Auton Neurosci 154:89-93 |
| Carter, Jason R; Klein, Jenna C; Schwartz, Christopher E (2010) Effects of oral contraceptives on sympathetic nerve activity during orthostatic stress in young, healthy women. Am J Physiol Regul Integr Comp Physiol 298:R9-R14 |
| Carter, Jason R; Lawrence, Johnathan E; Klein, Jenna C (2009) Menstrual cycle alters sympathetic neural responses to orthostatic stress in young, eumenorrheic women. Am J Physiol Endocrinol Metab 297:E85-91 |
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