Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Academic Research Enhancement Awards (AREA) (R15)
Project #
1R15NS038444-01
Application #
2810854
Study Section
Medicinal Chemistry Study Section (MCHA)
Program Officer
Baughman, Robert W
Project Start
1999-05-01
Project End
2002-06-30
Budget Start
1999-05-01
Budget End
2002-06-30
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Idaho
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Moscow
State
ID
Country
United States
Zip Code
83844
Steiger, Scott A; Li, Chun; Backos, Donald S et al. (2017) Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter. Bioorg Med Chem 25:3223-3234
Steiger, Scott A; Li, Chun; Campana, Charles F et al. (2016) Lanthanide and asymmetric catalyzed syntheses of sterically hindered 4-isoxazolyl-1,4-dihydropyridines and 4-isoxazolyl-quinolones. Tetrahedron Lett 57:423-425
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Szabon-Watola, Monika I; Ulatowski, Sarah V; George, Kathleen M et al. (2014) Fluorescent probes of the isoxazole-dihydropyridine scaffold: MDR-1 binding and homology model. Bioorg Med Chem Lett 24:117-21
Matti, Afnan A; Mirzaei, Joseph; Rudolph, John et al. (2013) Microwave accelerated synthesis of isoxazole hydrazide inhibitors of the system xc- transporter: Initial homology model. Bioorg Med Chem Lett 23:5931-5
Mirzaei, Yousef R; Weaver, Matthew J; Steiger, Scott A et al. (2012) Improved synthesis of 3-aryl isoxazoles containing fused aromatic rings. Tetrahedron 68:10360-10364
Hulubei, Victoria; Meikrantz, Scott B; Quincy, David A et al. (2012) 4-Isoxazolyl-1,4-dihydropyridines exhibit binding at the multidrug-resistance transporter. Bioorg Med Chem 20:6613-20
Patel, Sarjubhai A; Rajale, Trideep; O'Brien, Erin et al. (2010) Isoxazole analogues bind the system xc- transporter: structure-activity relationship and pharmacophore model. Bioorg Med Chem 18:202-13
Gajewski, Mariusz P; Beall, Howard; Schnieder, Mark et al. (2009) Bis-anthracenyl isoxazolyl amides have enhanced anticancer activity. Bioorg Med Chem Lett 19:4067-9
Han, Xiaochun; Li, Chun; Mosher, Michael D et al. (2009) Design, synthesis and biological evaluation of a novel class of anticancer agents: anthracenylisoxazole lexitropsin conjugates. Bioorg Med Chem 17:1671-80

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