This project establishes a Treatment Research Unit that focuses on reducing intravenous drug use to lower the risks of acquiring or spreading the Human Immunodeficiency Virus (HIV). The project's long-term objective is to improve the effectiveness of outpatient treatments for people addicted to opiates, cocaine, and other abused drugs.
The specific aims of the San Francisco Treatment Research Unit are: (1) To conduct high-quality research that evaluates innovative outpatient treatment strategies for drug abuse as a means of AIDs risk reduction. The focal point of the Treatment Research Unit will be a long-term outpatient detoxification research clinic, whill will study the efficacy of interventions to move drug abusers toward a drug-free life. (2) To stimulate treatment research in associated community clinics to improve the efficacy of outpatient treatment of opiate and cocaine abuse. (3) To foster collaboration and communication among scientists and practitioners as a way to stimulate new research improving the efficacy of drug abuse treatment. The Unit will disseminate the results of studies to clinicians, scientists, and the public. A Scientific Advisory Group will review and approve research plans and protocols. They will provide policy guidance and will conduct periodic reviews of the Unit's activities. The Unit will establish a core battery for assessment of treatment outcome and measurement of the impact of treatment on HIV. The Unit's dissemination activities will reach treatment programs with specific AIDS prevention techniques and will disseminate improved techniques nationally. This proposal is part of an effort to slow the spread of HIV among drug abusers.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Demonstration and Dissemination Projects (R18)
Project #
Application #
Study Section
Special Emphasis Panel (SRCD (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Francisco
Schools of Medicine
San Francisco
United States
Zip Code
Sorensen, J L; Jacob, C; Dilley, J et al. (2000) Causes of death among substance users with HIV disease. AIDS 14:2047-9
Felix-Ortiz, M; Salazar, M R; Gonzalez, J R et al. (2000) A qualitative evaluation of an assisted self-help group for drug-addicted clients in a structured outpatient treatment setting. Community Ment Health J 36:339-50
Reid, M S; Mickalian, J D; Delucchi, K L et al. (1999) A nicotine antagonist, mecamylamine, reduces cue-induced cocaine craving in cocaine-dependent subjects. Neuropsychopharmacology 20:297-307
Hartz, D T; Meek, P; Piotrowski, N A et al. (1999) A cost-effectiveness and cost-benefit analysis of contingency contracting-enhanced methadone detoxification treatment. Am J Drug Alcohol Abuse 25:207-18
Piotrowski, N A; Tusel, D J; Sees, K L et al. (1999) Contingency contracting with monetary reinforcers for abstinence from multiple drugs in a methadone program. Exp Clin Psychopharmacol 7:399-411
Wasserman, D A; Korcha, R; Havassy, B E et al. (1999) Detection of illicit opioid and cocaine use in methadone maintenance treatment. Am J Drug Alcohol Abuse 25:561-71
Di Sclafani, V; Clark, H W; Tolou-Shams, M et al. (1998) Premorbid brain size is a determinant of functional reserve in abstinent crack-cocaine and crack-cocaine-alcohol-dependent adults. J Int Neuropsychol Soc 4:559-65
Maude-Griffin, P M; Hohenstein, J M; Humfleet, G L et al. (1998) Superior efficacy of cognitive-behavioral therapy for urban crack cocaine abusers: main and matching effects. J Consult Clin Psychol 66:832-7
Sorensen, J L; Mascovich, A; Wall, T L et al. (1998) Medication adherence strategies for drug abusers with HIV/AIDS. AIDS Care 10:297-312
Reid, M S; Mickalian, J D; Delucchi, K L et al. (1998) An acute dose of nicotine enhances cue-induced cocaine craving. Drug Alcohol Depend 49:95-104

Showing the most recent 10 out of 54 publications